Repair Strategies and Bioactive Functional Materials for Intervertebral Disc
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202209471
Abstract: Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which represents a highly prevalent chronic aging‐associated disorder with a large socio‐economic burden and a great decline in the quality of life, contributing… read more here.
Keywords: repair strategies; strategies bioactive; functional materials; intervertebral disc ... See more keywords
Multifunctional Nanofibrous Scaffolds with Angle‐Ply Microstructure and Co‐Delivery Capacity Promote Partial Repair and Total Replacement of Intervertebral Disc
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200895
Abstract: There is an urgent clinical need for the treatment of annulus fibrosus (AF) impairment caused by intervertebral disc (IVD) degeneration or surgical injury. Although repairing injured AF through tissue engineering is promising, the approach is… read more here.
Keywords: ply microstructure; replacement; multifunctional nanofibrous; nanofibrous scaffolds ... See more keywords
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced science"
DOI: 10.1002/advs.202104888
Abstract: Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack… read more here.
Keywords: pronps; degeneration; nucleus pulposus; intervertebral disc ... See more keywords
Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202206296
Abstract: The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, a single‐cell transcriptomic atlas mapping early IVD formation is still… read more here.
Keywords: cell; ivd; single cell; intervertebral disc ... See more keywords
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202207216
Abstract: Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based on sequencing analyses of IVDD patients from the gene expression omnibus (GEO) databases.… read more here.
Keywords: iron; disc degeneration; intervertebral disc; ferroptosis ... See more keywords
Position of Lumbar Plexus Nerves in the Psoas Major: Application to Transpsoas Approaches to the Lumbar Spine.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical anatomy"
DOI: 10.1002/ca.24016
Abstract: OBJECTIVE Far lateral interbody fusion is a minimally invasive operating technique. However, the incidence of postoperative neurological complications is high, and some scholars question its safety. This study describes the neuroanatomical features and spatial orientation… read more here.
Keywords: position lumbar; psoas major; nerves psoas; zone intervertebral ... See more keywords
PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors
Sign Up to like & getrecommendations! Published in 2019 at "Cell Biology International"
DOI: 10.1002/cbin.11258
Abstract: Intervertebral disc degeneration (IDD) is induced by multiple factors including increased apoptosis, decreased survival, and reduced extracellular matrix (ECM) synthesis in the nucleus pulposus (NP) cells. The tumor suppressor phosphatase and tensin homolog deleted from… read more here.
Keywords: disc; pi3k akt; intervertebral disc; nucleus pulposus ... See more keywords
Understanding embryonic development for cell‐based therapies of intervertebral disc degeneration: Toward an effort to treat disc degeneration subphenotypes
Sign Up to like & getrecommendations! Published in 2020 at "Developmental Dynamics"
DOI: 10.1002/dvdy.217
Abstract: Chronic low back and neck pain are associated with intervertebral disc degeneration and are major contributors to the global burden of disability. New evidence now suggests that disc degeneration comprises a spectrum of subphenotypes influenced… read more here.
Keywords: based therapies; degeneration; cell based; intervertebral disc ... See more keywords
The P2X7 purinergic receptor in intervertebral disc degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cellular physiology"
DOI: 10.1002/jcp.30611
Abstract: Mechanisms involved in the development of intervertebral disc (IVD) degeneration are only partially known, thus making the implementation of effective therapies very difficult. In this study, we investigated P2X7 purinergic receptor (P2X7R), NLRP3 inflammasome, and… read more here.
Keywords: p2x7r nlrp3; p2x7r; intervertebral disc; purinergic receptor ... See more keywords
Conus medullaris migration during the third trimester: A retrospective study.
Sign Up to like & getrecommendations! Published in 2021 at "Prenatal diagnosis"
DOI: 10.1002/pd.6062
Abstract: OBJECTIVE To explore the migration process of the conus medullaris (CM) and propose a normal range of CM levels during the third trimester. METHOD We retrospectively collected the ultrasonographic and clinical data of 588 fetuses… read more here.
Keywords: conus medullaris; level; third trimester; migration ... See more keywords
Evaluation of intervertebral disc using T2 mapping sequences in patients undergoing O2–O3 chemiodiscolysis: an instrumental study with clinical correlation
Sign Up to like & getrecommendations! Published in 2019 at "Neuroradiology"
DOI: 10.1007/s00234-019-02308-8
Abstract: PurposeTo assess the MRI modifications of the intervertebral disc (IVD) treated by chemiodiscolysis using T2 mapping sequences.MethodsThirty sciatica patients (17 males, 13 females, mean age 47.52 years) were enrolled for percutaneous CT-guided O2–O3 chemiodiscolysis treatment.… read more here.
Keywords: treatment; correlation; chemiodiscolysis; intervertebral disc ... See more keywords