Repair Strategies and Bioactive Functional Materials for Intervertebral Disc
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DOI: 10.1002/adfm.202209471
Abstract: Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which represents a highly prevalent chronic aging‐associated disorder with a large socio‐economic burden and a great decline in the quality of life, contributing… read more here.
Keywords: repair strategies; strategies bioactive; functional materials; intervertebral disc ... See more keywords
Photothermal Hydrogel with Mn3O4 Nanoparticles Alleviates Intervertebral Disc Degeneration by Scavenging ROS and Regulating Extracellular Matrix Metabolism
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DOI: 10.1002/adfm.202422817
Abstract: Annulus fibrosus (AF) injury plays a critical role in intervertebral disc degeneration (IVDD), with oxidative stress and extracellular matrix (ECM) imbalance being major pathogenic factors. However, effective repair methods are limited. In this study, an… read more here.
Keywords: mn3o4; disc degeneration; intervertebral disc; extracellular matrix ... See more keywords
Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration
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DOI: 10.1002/adfm.202504775
Abstract: Ferroptosis is a major contributor to intervertebral disc degeneration (IVDD) and represents a promising therapeutic target; however, effective medications that specifically target ferroptosis are still lacking. Consequently, strategies aimed at suppressing the expression of ferroptosis‐related… read more here.
Keywords: disc degeneration; intervertebral disc; sirna delivery; delivery ... See more keywords
Multifunctional Nanofibrous Scaffolds with Angle‐Ply Microstructure and Co‐Delivery Capacity Promote Partial Repair and Total Replacement of Intervertebral Disc
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DOI: 10.1002/adhm.202200895
Abstract: There is an urgent clinical need for the treatment of annulus fibrosus (AF) impairment caused by intervertebral disc (IVD) degeneration or surgical injury. Although repairing injured AF through tissue engineering is promising, the approach is… read more here.
Keywords: ply microstructure; replacement; multifunctional nanofibrous; nanofibrous scaffolds ... See more keywords
Injectable Nanocomposite Hydrogels for Intervertebral Disc Degeneration: Combating Oxidative Stress, Mitochondrial Dysfunction, and Ferroptosis
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DOI: 10.1002/adhm.202403892
Abstract: Intervertebral disc degeneration (IVDD) is a major cause of low back pain, where oxidative stress and mitochondrial dysfunction are key contributors. Additionally, ferroptosis, an iron‐dependent form of cell death, is identified as a critical mechanism… read more here.
Keywords: disc degeneration; intervertebral disc; oxidative stress; mitochondrial dysfunction ... See more keywords
3D‐Printed Negative Poisson's Ratio Composite Scaffolds with Antibacterial and Microenvironment Remodeling Capacities for Ameliorating Intervertebral Disc Degeneration
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DOI: 10.1002/adhm.202502365
Abstract: During the process of intervertebral disc degeneration (IDD), localized inflammatory responses occur, triggering an imbalance in the decomposition and metabolism of nucleus pulposus (NP) cells, which subsequently leads to the functional impairment of the intervertebral… read more here.
Keywords: disc degeneration; intervertebral disc; negative poisson; poisson ratio ... See more keywords
Targeting MT-tsRNA IDDMT with Nanoparticles to Annulus Fibrosus: A Novel Therapeutic Approach for Intervertebral Disc Degeneration.
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DOI: 10.1002/adhm.202502795
Abstract: Annulus fibrosus (AF) injury is a significant cause of NP protrusion and intervertebral disc degeneration (IDD). Currently, the molecular mechanisms of IDD remain unclear, and there is a lack of methods for early diagnosis and… read more here.
Keywords: disc degeneration; intervertebral disc; annulus fibrosus; tsrna iddmt ... See more keywords
A One‐Stone‐Two–Birds Strategy for Intervertebral Disc Repair: Constructing a Reductive Chelation Hydrogel to Mitigate Oxidative Stress and Promote Disc Matrix Reconstruction
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DOI: 10.1002/adma.202411290
Abstract: Intervertebral disc degeneration (IVDD) is characterized by fibrosis of nucleus pulposus (NP) cells and accelerated surrounding extracellular matrix catabolism. Bioactive hydrogels have shown significant potential in regulating cellular functions and tissue homeostasis. In this work,… read more here.
Keywords: intervertebral disc; matrix; hydrogel; disc ... See more keywords
Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration.
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DOI: 10.1002/advs.202104888
Abstract: Intervertebral disc degeneration (IDD) results from the dysfunction of nucleus pulposus (NP) cells and the exhaustion of NP progenitors (ProNPs). The cellular applications of NP cells during IDD are currently limited due to the lack… read more here.
Keywords: pronps; degeneration; nucleus pulposus; intervertebral disc ... See more keywords
Spatiotemporal Characterization of Human Early Intervertebral Disc Formation at Single‐Cell Resolution
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DOI: 10.1002/advs.202206296
Abstract: The intervertebral disc (IVD) acts as a fibrocartilaginous joint to anchor adjacent vertebrae. Although several studies have demonstrated the cellular heterogeneity of adult mature IVDs, a single‐cell transcriptomic atlas mapping early IVD formation is still… read more here.
Keywords: cell; ivd; single cell; intervertebral disc ... See more keywords
Polydopamine Nanoparticles Targeting Ferroptosis Mitigate Intervertebral Disc Degeneration Via Reactive Oxygen Species Depletion, Iron Ions Chelation, and GPX4 Ubiquitination Suppression
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DOI: 10.1002/advs.202207216
Abstract: Intervertebral disc degeneration (IVDD)‐induced lower back pain (LBP) is a common problem worldwide. The underlying mechanism is partially accredited to ferroptosis, based on sequencing analyses of IVDD patients from the gene expression omnibus (GEO) databases.… read more here.
Keywords: iron; disc degeneration; intervertebral disc; ferroptosis ... See more keywords