Bu‐Shen‐Huo‐Xue‐Fang modulates nucleus pulposus cell proliferation and extracellular matrix remodeling in intervertebral disk degeneration through miR‐483 regulation of Wnt pathway
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26760
Abstract: Intervertebral disk degeneration (IDD) has been widely considered as one of the main causes for low back pain, which can cause a severe impact to human health and huge economic burden to worldwide society. IDD… read more here.
Keywords: disk degeneration; cell proliferation; intervertebral disk; wnt ... See more keywords
Quantitative 23 Na-MRI of the intervertebral disk at 3T.
Sign Up to like & getrecommendations! Published in 2022 at "NMR in biomedicine"
DOI: 10.1002/nbm.4733
Abstract: Monitoring the tissue sodium content (TSC) in the intervertebral disk geometry non-invasively by MRI is sensitive measure to estimate the changes in the proteoglycan content of the intervertebral disk which is a biomarker of degenerative… read more here.
Keywords: geometry; disk; sodium concentration; sodium ... See more keywords
DEPTOR regulates nucleus pulposus cell senescence through the mTORC1/S6K1/ATG1 pathway to alleviate intervertebral disk degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02819-9
Abstract: This study aimed to determine the molecular mechanisms by which the DEP domain-containing mTOR-interacting protein (DEPTOR) regulates the senescence of nucleus pulposus (NP) cells (NPCs), alleviating intervertebral disk degeneration (IDD). This study investigated how DEPTOR… read more here.
Keywords: s6k1; intervertebral disk; mtorc1; deptor regulates ... See more keywords
Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration.
Sign Up to like & getrecommendations! Published in 2022 at "DNA and cell biology"
DOI: 10.1089/dna.2021.1012
Abstract: Low back pain (LBP) is a common disorder in orthopedic outpatients, affecting people of all ages, and some patients may develop chronic LBP. As a complex organelle, mitochondria are not only energy workstations but also… read more here.
Keywords: mitochondrial dysfunction; disk degeneration; dysfunction intervertebral; intervertebral disk ... See more keywords
Bibliometric Analysis of the 100 Most Cited Articles on Intervertebral Disk Research
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Spine Surgery"
DOI: 10.1097/bsd.0000000000000863
Abstract: Supplemental Digital Content is available in the text. Study Design: A bibliometric review of the literature. Object: To analyze and quantify the most frequently cited papers in intervertebral disk research. Summary of Background Data: The… read more here.
Keywords: cited articles; disk; intervertebral disk; study ... See more keywords
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration
Sign Up to like & getrecommendations! Published in 2018 at "Aging Cell"
DOI: 10.1111/acel.12800
Abstract: Intervertebral disk (IVD) degeneration is a prevalent age‐associated musculoskeletal disorder and a major cause of chronic low back pain. Aging is the main risk factor for the disease, but the molecular mechanisms regulating IVD homeostasis… read more here.
Keywords: homeostasis; intervertebral disk; foxo; homeostasis aging ... See more keywords
BRD4/MAP2K7/PGF Signaling Axis Promotes Senescence and Extracellular Matrix Metabolism of Nucleus Pulposus Cells in Intervertebral Disk Degeneration
Sign Up to like & getrecommendations! Published in 2025 at "Aging Cell"
DOI: 10.1111/acel.70034
Abstract: Intervertebral disk degeneration (IDD) is a common age‐related degenerative disease of the spine that imposes a substantial economic burden on both families and society. Despite substantial advances in understanding the mechanisms underlying IDD, effective therapeutic… read more here.
Keywords: senescence; intervertebral disk; metabolism; expression ... See more keywords
MiR-206 improves intervertebral disk degeneration by targeting GJA1
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-022-03044-1
Abstract: Background A large amount of evidence suggested that miRNA was involved in the progression of intervertebral disk degeneration (IDD). The purpose of our study was to explore the function and potential mechanism of miR-206/GJA1 axis… read more here.
Keywords: idd; gja1; disk degeneration; targeting gja1 ... See more keywords
Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Orthopaedic Surgery and Research"
DOI: 10.1186/s13018-024-04554-w
Abstract: Objective To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats. Methods Thirty male Sprague–Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The… read more here.
Keywords: intervertebral disk; disk degeneration; group; yougui wan ... See more keywords
Spinal magnetic resonance imaging in cats: differences in clinical significance of intervertebral disk extrusion, intervertebral disk protrusion, and degenerative lumbosacral stenosis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Veterinary Medical Association"
DOI: 10.2460/javma.24.02.0099
Abstract: OBJECTIVE To determine the occurrence of degenerative changes affecting the vertebral column in cats, assess their clinical significance, and determine the occurrence in cats with intervertebral disk herniation compared to other spinal diseases. ANIMALS 114… read more here.
Keywords: disk extrusion; intervertebral disk; disk; clinical significance ... See more keywords
Intervertebral Disk Degeneration: The Microenvironment and Tissue Engineering Strategies
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2021.592118
Abstract: Intervertebral disk degeneration (IVDD) is a leading cause of disability. The degeneration is inevitable, and the mechanisms are complex. Current therapeutic strategies mainly focus on the relief of symptoms, not the intrinsic regeneration of the… read more here.
Keywords: intervertebral disk; engineering strategies; tissue engineering; tissue ... See more keywords