Shortcuts to intestinal carcinogenesis by genetic engineering in organoids
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DOI: 10.1111/cas.13938
Abstract: Inactivation of the Adenomatous polyposis coli (APC) gene is an initiating and the most relevant event in most sporadic cases of colorectal cancer, providing a rationale for using Apc‐mutant mice as the disease model. Whereas… read more here.
Keywords: shortcuts intestinal; carcinogenesis genetic; intestinal carcinogenesis; cancer ... See more keywords
Microbial metabolite deoxycholic acid promotes vasculogenic mimicry formation in intestinal carcinogenesis.
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DOI: 10.1111/cas.15208
Abstract: High-fat diet (HFD) leads to long-term exposure to gut microbial metabolite secondary bile acids such as deoxycholic acid (DCA) in the intestine, which is closely linked to colorectal cancer (CRC). Evidence reveals that vasculogenic mimicry… read more here.
Keywords: microbial metabolite; intestinal carcinogenesis; emt; formation ... See more keywords