Nutritional modulation of intestinal drug-metabolizing cytochrome P450 by butyrate of different origin in chicken.
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.07.033
Abstract: Intestinal cytochrome P450 (CYP) enzymes play key role in the first pass metabolism of orally ingested xenobiotics, providing a primary metabolic barrier, being of special importance in maintaining animal health and production. This study was… read more here.
Keywords: different origin; drug metabolizing; butyrate; intestinal drug ... See more keywords
Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2017.04.004
Abstract: In recent years, an increasing number of clinical drug-drug interactions (DDIs) have been attributed to inhibition of intestinal organic anion-transporting polypeptides (OATPs); however, only a few of these DDI results were reflected in drug labels.… read more here.
Keywords: oatps systematic; drug interactions; mediated oatps; drug ... See more keywords
A proof of concept using the Ussing chamber methodology to study pediatric intestinal drug transport and age‐dependent differences in absorption
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Science"
DOI: 10.1111/cts.13368
Abstract: Little is known about the impact of age on the processes governing human intestinal drug absorption. The Ussing chamber is a system to study drug transport across tissue barriers, but it has not been used… read more here.
Keywords: methodology; ussing chamber; transport; intestinal drug ... See more keywords
Ontogeny of Small Intestinal Drug Transporters and Metabolizing Enzymes Based on Targeted Quantitative Proteomics
Sign Up to like & getrecommendations! Published in 2021 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.121.000559
Abstract: Most drugs are administered to children orally. An information gap remains on the protein abundance of small intestinal drug-metabolizing enzymes (DMEs) and drug transporters (DTs) across the pediatric age range, which hinders precision dosing in… read more here.
Keywords: ileum; age; small intestinal; drug ... See more keywords
Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation
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DOI: 10.3390/pharmaceutics13020272
Abstract: The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these… read more here.
Keywords: absorption; drug absorption; regional intestinal; absorption biopharmaceutics ... See more keywords
Strategies and Mechanism in Reversing Intestinal Drug Efflux in Oral Drug Delivery
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DOI: 10.3390/pharmaceutics14061131
Abstract: Efflux transporters distributed at the apical side of human intestinal epithelial cells actively transport drugs from the enterocytes to the intestinal lumen, which could lead to extremely poor absorption of drugs by oral administration. Typical… read more here.
Keywords: oral drug; drug efflux; intestinal drug; drug ... See more keywords