Tryptophan Metabolite Activation of the Aryl Hydrocarbon Receptor Regulates IL10 Receptor Expression on Intestinal Epithelia
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal immunology"
DOI: 10.1038/mi.2016.133
Abstract: IL-10 is a potent anti-inflammatory cytokine that inhibits the production of proinflammatory mediators. Signaling by IL-10 occurs through the IL-10 receptor (IL-10R), which is expressed in numerous cell types, including intestinal epithelial cells (IECs), where… read more here.
Keywords: aryl hydrocarbon; intestinal epithelia; expression; 10r1 expression ... See more keywords
Desmoglein 2, but not desmocollin 2, protects intestinal epithelia from injury
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal Immunology"
DOI: 10.1038/s41385-018-0062-z
Abstract: Desmosomes are the least understood intercellular junctions in the intestinal epithelia and provide cell–cell adhesion via the cadherins desmoglein (Dsg)2 and desmocollin (Dsc)2. We studied these cadherins in Crohn’s disease (CD) patients and in newly… read more here.
Keywords: iec mice; dsg2 iec; intestinal epithelia; iec ... See more keywords
Heavy metal-laden particulate dust disrupts intestinal epithelial stem cells and lineage differentiation
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731105
Abstract: Chronic heavy metals exposure has been associated with intestinal inflammation and higher incidences of colorectal cancer, however there is no molecular evidence that metal laden-particulates can cause injury to the gut epithelia. Communities that live… read more here.
Keywords: uranium dust; dust; particulate dust; physiology ... See more keywords
Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia
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DOI: 10.3389/fmicb.2022.932294
Abstract: Abdominal irradiation (IR) destroys the intestinal mucosal barrier, leading to severe intestinal infection. There is an urgent need to find safe and effective treatments to reduce IR-induced intestinal injury. In this study, we reported that… read more here.
Keywords: induced intestinal; abundance; intestinal epithelia; intestinal injury ... See more keywords
Uptake of Tropheryma whipplei by Intestinal Epithelia
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DOI: 10.3390/ijms24076197
Abstract: Background: Tropheryma whipplei (TW) can cause different pathologies, e.g., Whipple’s disease and transient gastroenteritis. The mechanism by which the bacteria pass the intestinal epithelial barrier, and the mechanism of TW-induced gastroenteritis are currently unknown. Methods:… read more here.
Keywords: whipplei intestinal; uptake tropheryma; tropheryma whipplei; intestinal epithelia ... See more keywords