miR‐126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis‐associated colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13218
Abstract: Inflammatory bowel disease, characterised by chronic relapsing‐remitting colitis, is a significant risk factor for colorectal cancer (CRC). Previously, we showed that miR‐126 functions as a tumour suppressor in CRC and is inversely correlated with tumour… read more here.
Keywords: colitis associated; colitis; colorectal cancer; mir 126 ... See more keywords
Adrenomedullin alleviates mucosal injury in experimental colitis and increases claudin‐4 expression in the colonic epithelium
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13577
Abstract: Adrenomedullin (AM) is a peptide with pleiotropic physiological functions that attenuates intestinal mucosal inflammation. However, the mechanism underpinning mucosal protection by AM is not fully understood, and its effect on intestinal epithelial cells remains unclear.… read more here.
Keywords: expression; claudin expression; adrenomedullin alleviates; colitis ... See more keywords
Culture of Intestinal Epithelial Cell Monolayers and Their Use in Multiplex Macromolecular Permeability Assays for In Vitro Analysis of Tight Junction Size Selectivity
Sign Up to like & getrecommendations! Published in 2020 at "Current Protocols in Immunology"
DOI: 10.1002/cpim.112
Abstract: Tight junctions form a selectively permeable barrier that limits paracellular flux across epithelial‐lined surfaces. Small molecules (less than ∼8 Å diameter) can traverse the junction via the size‐ and charge‐selective, high‐conductance pore pathway. In contrast,… read more here.
Keywords: epithelial cell; intestinal epithelial; cell monolayers; size ... See more keywords
Fumonisin B1 damages the barrier functions of porcine intestinal epithelial cells in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22397
Abstract: Fumonisins (Fums) are mycotoxins widely distributed in crops and feed, and ingestion of Fums‐contaminated crops is harmful to animal health. The purpose of this study is to explore the effect of Fum B1 (FB1) on… read more here.
Keywords: epithelial cells; functions porcine; intestinal epithelial; porcine intestinal ... See more keywords
VSL#3 probiotic differently influences IEC‐6 intestinal epithelial cell status and function
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.25814
Abstract: The data here reported introduce the wound‐healing assay as a tool for testing probiotics aimed at protecting gastrointestinal mucosal surfaces and to verify the consistency of their manufacturing. At the scope, we compared the in… read more here.
Keywords: made vsl; epithelial cell; intestinal epithelial; italy made ... See more keywords
N‐(3‐oxododecanoyl)‐l‐homoserine lactone disrupts intestinal epithelial barrier through triggering apoptosis and collapsing extracellular matrix and tight junction
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30261
Abstract: Microbes employ autoinducers of quorum sensing (QS) for population communication. Although the autoinducer of Pseudomonas aeruginosa LasI‐LasR system, N‐(3‐oxododecanoyl)‐ l‐homoserine lactone (3OC12), has been reported with deleterious effects on host cells, its biological effects on… read more here.
Keywords: intestinal epithelial; 3oc12 3oc14; apoptosis; epithelial barrier ... See more keywords
How do immune and mesenchymal cells influence the intestinal epithelial cell compartment in inflammatory bowel disease? Let's crosstalk about it!
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3mir0120-567r
Abstract: Intestinal epithelial cells provide a front line of defense by establishing a barrier against food Ags, pathogens, and commensal microorganisms. This defense includes the establishment of a tolerogenic environment in the gastrointestinal (GI) tract. The… read more here.
Keywords: inflammatory bowel; biology; influence intestinal; cell ... See more keywords
Leucine Protects Bovine Intestinal Epithelial Cells from Hydrogen Peroxide-Induced Apoptosis by Alleviating Oxidative Damage.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.11941
Abstract: BACKGROUND The aim of this study was to investigate whether leucine (Leu) alleviates oxidative injury in bovine intestinal epithelial cells (BIECs) induced by hydrogen peroxide (H2 O2 ) and the underlying molecular mechanisms. RESULTS BIECs… read more here.
Keywords: hydrogen peroxide; apoptosis; epithelial cells; leu ... See more keywords
Paeoniflorin‐6′‐O‐benzene sulfonate protected the intestinal epithelial barrier by restoring the inhibitory effect of GRK2 and β‐arrestin 2 on ERK1/2‐NF‐κB
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7657
Abstract: Peoniflorin‐6′‐O‐benzene sulfonate (CP‐25) inhibited the activity of GRK2 to exert anti‐inflammatory and immunomodulatory effects. This study aimed to investigate the effect of CP‐25 the intestinal epithelial barrier and the mechanism. CaCO‐2 cell monolayer and dextran… read more here.
Keywords: epithelial barrier; barrier; grk2 arrestin; intestinal epithelial ... See more keywords
Autophagic response of intestinal epithelial cells exposed to polystyrene nanoplastics
Sign Up to like & getrecommendations! Published in 2022 at "Environmental Toxicology"
DOI: 10.1002/tox.23678
Abstract: Growing evidence demonstrates that the bioaccumulation of polystyrene nanoplastics (PS‐NPs) in the gastrointestinal tract has negative effects on health. Until now, little information has been available regarding the potential hazards of PS‐NPs to intestinal epithelial… read more here.
Keywords: autophagic response; polystyrene nanoplastics; response intestinal; epithelial cells ... See more keywords
Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04081-5
Abstract: Keratin 8 (K8) is the main intestinal epithelial intermediate filament protein with proposed roles for colonic epithelial cell integrity. Here, we used mice lacking K8 in intestinal epithelial cells (floxed K8 and Villin-Cre1000 and Villin-CreERt2)… read more here.
Keywords: intestinal epithelial; integrity; epithelial cells; targeted deletion ... See more keywords