Controversial Contribution of Th17/IL-17 Toward the Immune Response in Intestinal Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06161-1
Abstract: Intestinal fibrosis is a common outcome of inflammatory bowel diseases (IBDs), becoming clinically apparent in 40% of patients with Crohn’s disease and 5% of those with ulcerative colitis. Effective pharmacological treatments aimed at controlling or… read more here.
Keywords: intestinal fibrosis; fibrosis; contribution; immune response ... See more keywords
Intestinal fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2018.10.003
Abstract: Extensive tissue fibrosis is the end-stage process of a number of chronic conditions affecting the gastrointestinal tract, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), ulcerative jejunoileitis, and radiation enteritis. Fibrogenesis is a physiological, reparative… read more here.
Keywords: process; intestinal fibrosis; fibrosis; tissue ... See more keywords
Integrin αvβ6 contributes to the development of intestinal fibrosis via the FAK/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.113003
Abstract: Intestinal fibrosis is one of the most severe complications of inflammatory bowel disease (IBD) and frequently requires surgery due to intestinal obstruction. Integrin αvβ6, which is mainly regulated by the integrin β6 subunit gene (ITGB6),… read more here.
Keywords: development; mice; fak akt; intestinal fibrosis ... See more keywords
Inflammation independent TL1A-mediated Intestinal Fibrosis is Dependent on the Gut Microbiome
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0055-y
Abstract: Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and associated with… read more here.
Keywords: intestinal fibrosis; fibrosis; tl1a; tl1a mediated ... See more keywords
Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
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DOI: 10.1038/s41598-021-94280-8
Abstract: Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD). It is a challenge to identify environmental factors such as diet that may be driving this risk. Intestinal fibrosis result from accumulation of extracellular… read more here.
Keywords: dietary salt; intestinal fibrosis; fibrosis; tnbs ... See more keywords
Development and Validation of a Novel Computed-Tomography Enterography Radiomic Approach for Characterization of Intestinal Fibrosis in Crohn's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.02.027
Abstract: BACKGROUND & AIMS No reliable method for evaluating intestinal fibrosis in Crohn's disease (CD) exists; therefore, we developed a computed-tomography enterography (CTE)-based radiomic model (RM) for characterising intestinal fibrosis in CD. METHODS This retrospective-multicentre study… read more here.
Keywords: computed tomography; intestinal fibrosis; fibrosis; tomography enterography ... See more keywords
Th17 cell-derived amphiregulin promotes colitis-associated intestinal fibrosis through activation of mTOR and MEK in intestinal myofibroblasts.
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology"
DOI: 10.1053/j.gastro.2022.09.006
Abstract: BACKGROUND & AIMS Intestinal fibrosis is a significant complication of Crohn's disease (CD). Gut microbiota reactive Th17 cells are crucial in the pathogenesis of CD; however, how Th17 cells induce intestinal fibrosis is still not… read more here.
Keywords: th17 cells; expression; intestinal fibrosis; areg ... See more keywords
NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2023.2145029
Abstract: Abstract Aim Radiation-induced intestinal fibrosis, a common complication of long-term survivors after receiving abdominal and pelvic radiotherapy, has no effective clinical drugs at present. Nicotinamide mononucleotide (NMN) has been reported to alleviate a variety of… read more here.
Keywords: intestinal fibrosis; radiation; microbiota; gut microbiota ... See more keywords
Crohn’s disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2193115
Abstract: ABSTRACT The interaction between adherent-invasive Escherichia coli (AIEC) and intestinal macrophages is implicated in the pathogenesis of Crohn’s disease (CD). However, its role in intestinal fibrogenesis and the underlying molecular mechanisms are poorly understood. In… read more here.
Keywords: let; crohn disease; intestinal fibrosis; let expression ... See more keywords
AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
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DOI: 10.1093/ibd/izaa169
Abstract: BACKGROUND Fibrosis is the final common pathway to intestinal failure in Crohn's disease, but no medical therapies exist to treat intestinal fibrosis. Activated myofibroblasts are key effector cells of fibrosis in multiple organ systems, including… read more here.
Keywords: potential target; models intestinal; intestinal fibrosis; fibrosis ... See more keywords
Serum biomarkers of fibrostenotic Crohn's disease: Where are we now?
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Digestive Diseases"
DOI: 10.1111/1751-2980.12913
Abstract: Intestinal fibrosis and subsequent stricture formation are major clinical challenges in inflammatory bowel disease, resulting in an increased rate of operation and poor prognosis compared with those without. With the changing perception that intestinal fibrosis… read more here.
Keywords: intestinal fibrosis; serum biomarkers; disease; biomarkers fibrostenotic ... See more keywords