Controversial Contribution of Th17/IL-17 Toward the Immune Response in Intestinal Fibrosis
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06161-1
Abstract: Intestinal fibrosis is a common outcome of inflammatory bowel diseases (IBDs), becoming clinically apparent in 40% of patients with Crohn’s disease and 5% of those with ulcerative colitis. Effective pharmacological treatments aimed at controlling or… read more here.
Keywords: intestinal fibrosis; fibrosis; contribution; immune response ... See more keywords
Intestinal fibrosis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular aspects of medicine"
DOI: 10.1016/j.mam.2018.10.003
Abstract: Extensive tissue fibrosis is the end-stage process of a number of chronic conditions affecting the gastrointestinal tract, including inflammatory bowel disease (Crohn's disease, ulcerative colitis), ulcerative jejunoileitis, and radiation enteritis. Fibrogenesis is a physiological, reparative… read more here.
Keywords: process; intestinal fibrosis; fibrosis; tissue ... See more keywords
Integrin αvβ6 contributes to the development of intestinal fibrosis via the FAK/AKT signaling pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2021.113003
Abstract: Intestinal fibrosis is one of the most severe complications of inflammatory bowel disease (IBD) and frequently requires surgery due to intestinal obstruction. Integrin αvβ6, which is mainly regulated by the integrin β6 subunit gene (ITGB6),… read more here.
Keywords: development; mice; fak akt; intestinal fibrosis ... See more keywords
Aryl Hydrocarbon Receptor Activation Limits the Fatty Acid Synthesis and Subsequent "miR-193a-3p-HDAC3-FASN" Signals to Alleviate Intestinal Fibrosis.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.4c00976
Abstract: Intestinal fibrosis is a common complication of Crohn's disease and characterized by excessive extracellular matrix (ECM) deposition. The aryl hydrocarbon receptor (AhR) detects micronutrients and microbial metabolites in diet and can attenuate intestinal fibrosis with… read more here.
Keywords: acid synthesis; activation; intestinal fibrosis; mir 193a ... See more keywords
Naringenin Alleviates the Autophagy-Associated AMPK-Akt/mTOR Pathway to Regulate Inflammation and Barrier Function, Decreasing DSS-Induced Intestinal Fibrosis
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DOI: 10.1021/acsomega.5c03232
Abstract: The development of strictures due to intestinal fibrosis remains a significant clinical challenge in patients with ulcerative colitis (UC). The purpose of this experiment was to investigate the protective effects of naringenin (NAR, 40 mg/kg),… read more here.
Keywords: fibrosis; akt mtor; intestinal fibrosis; ampk akt ... See more keywords
Inflammation independent TL1A-mediated Intestinal Fibrosis is Dependent on the Gut Microbiome
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0055-y
Abstract: Tumor necrosis factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease (IBD), modulating the location and severity of intestinal inflammation and fibrosis. TL1A expression is increased in inflamed gut mucosa and associated with… read more here.
Keywords: intestinal fibrosis; fibrosis; tl1a; tl1a mediated ... See more keywords
SAA3 deficiency exacerbates intestinal fibrosis in DSS-induced IBD mouse model
Sign Up to like & getrecommendations! Published in 2025 at "Cell Death Discovery"
DOI: 10.1038/s41420-025-02299-x
Abstract: Intestinal fibrosis, as a late-stage complication of inflammatory bowel disease (IBD), leads to bowel obstruction and requires surgical intervention, significantly lowering the quality of life of affected patients. SAA3, a highly conserved member of the… read more here.
Keywords: dss; ibd mouse; fibrosis; mouse model ... See more keywords
Mineralocorticoid receptor activation contributes to intestinal fibrosis through neutrophil gelatinase-associated lipocalin in preclinical models
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61401-0
Abstract: Intestinal fibrosis is a common complication in inflammatory bowel diseases with no specific therapy. Because mineralocorticoid receptor antagonism prevented inflammation and fibrosis in extra-intestinal organs, we aimed to evaluate mineralocorticoid receptor antagonism in intestinal fibrosis.… read more here.
Keywords: fibrosis; gelatinase associated; neutrophil gelatinase; mineralocorticoid receptor ... See more keywords
Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-94280-8
Abstract: Intestinal fibrosis is a frequent complication in inflammatory bowel diseases (IBD). It is a challenge to identify environmental factors such as diet that may be driving this risk. Intestinal fibrosis result from accumulation of extracellular… read more here.
Keywords: dietary salt; intestinal fibrosis; fibrosis; tnbs ... See more keywords
Hongyuyin attenuates intestinal fibrosis in ulcerative colitis in mice revealed by transcriptomic and network pharmacology analyses
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-06021-w
Abstract: Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease affecting the gastrointestinal tract. Hongyuyin (HYY), a traditional Chinese botanical formulation, has been effectively treating UC for over three decades; however, its underlying biological mechanism of… read more here.
Keywords: network pharmacology; pharmacology; intestinal fibrosis; ulcerative colitis ... See more keywords
Development and Validation of a Novel Computed-Tomography Enterography Radiomic Approach for Characterization of Intestinal Fibrosis in Crohn's Disease.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.02.027
Abstract: BACKGROUND & AIMS No reliable method for evaluating intestinal fibrosis in Crohn's disease (CD) exists; therefore, we developed a computed-tomography enterography (CTE)-based radiomic model (RM) for characterising intestinal fibrosis in CD. METHODS This retrospective-multicentre study… read more here.
Keywords: computed tomography; intestinal fibrosis; fibrosis; tomography enterography ... See more keywords