Co‐existing colloidal phases in artificial intestinal fluids assessed by AF4/MALLS and DLS: A systematic study into cholate & (lyso‐) phospholipid blends, incorporating celecoxib as a model drug
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ejps.2018.04.031
Abstract: &NA; Colloidal phases (self‐assemblies) in aqueous dispersions of selected binary bile salt/phospholipid blends were studied utilizing the combined analytical approach of asymmetrical flow field‐flow fractionation (AF4) and multi‐angle laser light scattering (MALLS) in order to… read more here.
Keywords: intestinal fluids; bile salt; colloidal phases; colloidal ... See more keywords
Molecular Dynamics Simulations on Interindividual Variability of Intestinal Fluids: Impact on Drug Solubilization
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.0c00588
Abstract: Efficient delivery of oral drugs is dependent on their solubility in human intestinal fluid, a complex and dynamic fluid that contains colloidal structures composed of small molecules. These structures solubilize poorly water-soluble compounds, increasing their… read more here.
Keywords: intestinal fluids; molecular dynamics; fluid; interindividual variability ... See more keywords
75 Evaluating the in vitro release of essential oils from microparticles in simulated swine gastric and intestinal fluids and the essential oil stability in microparticles during feed pelleting process
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Animal Science"
DOI: 10.1093/jas/skz258.145
Abstract: Essential oils are defined as plant-derived natural bioactive compounds with positive effects on animal growth and health due to their antimicrobial and antioxidative properties. However, essential oils are very volatile, can evaporate rapidly and be… read more here.
Keywords: essential oil; pelleting process; intestinal fluids; stability ... See more keywords