Intestinal HIF-2α Regulates GLP-1 Secretion via Lipid Sensing in L-Cells
Sign Up to like & getrecommendations! Published in 2021 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2021.12.004
Abstract: Background & Aims Compelling evidence shows that glucagon-like peptide-1 (GLP-1) has a profound effect in restoring normoglycemia in type 2 diabetic patients by increasing pancreatic insulin secretion. Although L-cells are the primary source of circulating… read more here.
Keywords: hif regulates; hif; glp secretion; secretion ... See more keywords
Hepatic hepcidin/intestinal HIF-2&agr; axis maintains iron absorption during iron deficiency and overload
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Investigation"
DOI: 10.1172/jci122359
Abstract: Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls iron mobilization through its molecular target ferroportin (FPN), the only known mammalian iron exporter. This pathway… read more here.
Keywords: overload; intestinal hif; iron; hif agr ... See more keywords