Tryptophan and the innate intestinal immunity: Crosstalk between metabolites, host innate immune cells and microbiota.
Sign Up to like & getrecommendations! Published in 2022 at "European journal of immunology"
DOI: 10.1002/eji.202149401
Abstract: The intestinal mucosal barrier is critical for the absorption of nutrients and the health of both humans and animals. Recent publications from clinical and experimental studies have shown the importanceof the nutrients-bacteria-host interaction for the… read more here.
Keywords: immune; tryptophan innate; host; intestinal homeostasis ... See more keywords
Intestinal homeostasis and inflammation: Gut microbiota at the crossroads of pancreas–intestinal barrier axis
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Immunology"
DOI: 10.1002/eji.202149532
Abstract: The pancreas contains exocrine glands, which release enzymes (e.g., amylase, trypsin, and lipase) that are important for digestion and islets, which produce hormones. Digestive enzymes and hormones are secreted from the pancreas into the duodenum… read more here.
Keywords: gut; pancreas intestinal; gut microbiota; intestinal homeostasis ... See more keywords
Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.
Sign Up to like & getrecommendations! Published in 2020 at "Immunity"
DOI: 10.1016/j.immuni.2020.10.014
Abstract: The gastrointestinal tract is known as the largest endocrine organ that encounters and integrates various immune stimulations and neuronal responses due to constant environmental challenges. Enterochromaffin (EC) cells, which function as chemosensors on the gut… read more here.
Keywords: interleukin promotes; enterochromaffin cells; intestinal homeostasis; promotes serotonin ... See more keywords
Cellular Plasticity in Intestinal Homeostasis and Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.11.019
Abstract: The intestinal epithelium is one the fastest renewing tissues in mammals and is endowed with extensive adaptability. The more traditional view of a hierarchical organization of the gut has recently given way to a more… read more here.
Keywords: homeostasis disease; plasticity intestinal; cellular plasticity; intestinal homeostasis ... See more keywords
The AIM2 inflammasome is a central regulator of intestinal homeostasis through the IL-18/IL-22/STAT3 pathway
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Immunology"
DOI: 10.1038/cmi.2016.35
Abstract: Inflammasomes are important for maintaining intestinal homeostasis, and dysbiosis contributes to the pathology of inflammatory bowel disease (IBD) and increases the risk for colorectal cancer. Inflammasome defects contribute to chronic intestinal inflammation and increase the… read more here.
Keywords: aim2 inflammasome; stat3 pathway; colorectal cancer; stat3 ... See more keywords
The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation
Sign Up to like & getrecommendations! Published in 2017 at "Mucosal Immunology"
DOI: 10.1038/mi.2017.88
Abstract: STING (stimulator of interferon genes) is a cytosolic sensor for cyclic dinucleotides and also an adaptor molecule for intracellular DNA receptors. Although STING has important functions in the host defense against pathogens and in autoimmune… read more here.
Keywords: homeostasis; inflammation; cytosolic sensor; sting mice ... See more keywords
Emc3 maintains intestinal homeostasis by preserving secretory lineages
Sign Up to like & getrecommendations! Published in 2021 at "Mucosal Immunology"
DOI: 10.1038/s41385-021-00399-2
Abstract: Intestinal exocrine secretory lineages, including goblet cells and Paneth cells, provide vital innate host defense to pathogens. However, how these cells are specified and maintained to ensure intestinal barrier function remains poorly defined. Here we… read more here.
Keywords: homeostasis; secretory lineages; maintains intestinal; intestinal homeostasis ... See more keywords
Orally administered mesoporous silica capped with the cucurbit[8]uril complex to combat colitis and improve intestinal homeostasis by targeting the gut microbiota.
Sign Up to like & getrecommendations! Published in 2020 at "Nanoscale"
DOI: 10.1039/d0nr03037f
Abstract: RATIONALE Inflammatory bowel diseases (IBDs) are still awaiting innovative treatments that can maximize the efficiency of site-specific drug release in the colon while enhancing intestinal homeostasis. METHODS Herein, we present multilayer-coated mesoporous silica (MSs) which… read more here.
Keywords: cucurbit uril; mesoporous silica; gut microbiota; intestinal homeostasis ... See more keywords
Intestinal homeostasis in autoimmune liver diseases
Sign Up to like & getrecommendations! Published in 2022 at "Chinese Medical Journal"
DOI: 10.1097/cm9.0000000000002291
Abstract: Abstract Intestinal homeostasis depends on complex interactions between the gut microbiota and host immune system. Emerging evidence indicates that the intestinal microbiota is a key player in autoimmune liver disease (AILD). Autoimmune hepatitis, primary biliary… read more here.
Keywords: homeostasis autoimmune; intestinal homeostasis; homeostasis; autoimmune liver ... See more keywords
Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade5079
Abstract: Outer membrane vesicles (OMVs) play vital roles in bacterial communication both intraspecifically and interspecifically. However, extracellular mechanisms of gut microbiota–derived OMVs in the intestine remain poorly understood. Here, we report that OMVs released from Akkermansia… read more here.
Keywords: regulating intestinal; gut microbiota; outer membrane; intestinal homeostasis ... See more keywords
Monoassociation with Lactobacillus plantarum Disrupts Intestinal Homeostasis in Adult Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2018 at "mBio"
DOI: 10.1128/mbio.01114-18
Abstract: ABSTRACT Adult Drosophila melanogaster raised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem… read more here.
Keywords: drosophila; host; intestinal homeostasis; monoassociation ... See more keywords