Papain‐Like Protease of SARS‐CoV‐2 Induces Intestinal Inflammation via the ISG15 Pathway: Identification of Natural Compound Inhibitors
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DOI: 10.1002/jmv.70448
Abstract: The SARS‐CoV‐2 papain‐like protease (PLpro) is a multifunctional viral protein that facilitates viral assembly and disrupts host immune responses by removing interferon‐stimulated gene 15 (ISG15) modifications from target proteins. However, the mechanisms by which PLpro‐mediated… read more here.
Keywords: sars cov; intestinal inflammation; like protease; papain like ... See more keywords
Cryptotanshinone protects dextran sulfate sodium‐induced experimental ulcerative colitis in mice by inhibiting intestinal inflammation
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DOI: 10.1002/ptr.6693
Abstract: The incidence of ulcerative colitis (UC) is increasing in recent years. The protective effect of cryptotanshinone, a natural compound from Salvia miltiorrhiza Bunge, on UC was investigated both in vivo and in vitro models. UC… read more here.
Keywords: dextran sulfate; sulfate sodium; intestinal inflammation; cryptotanshinone ... See more keywords
Assessment of intestinal inflammation via fecal calprotectin for early prediction of adverse outcomes in advanced chronic liver disease
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DOI: 10.1002/ueg2.12633
Abstract: Abstract Background and aims Intestinal inflammation assessed by fecal calprotectin (F‐CAL) in advanced chronic liver disease (ACLD) may represent an early sign of intestinal barrier dysfunction. We aimed to explore the usefulness of F‐CAL testing… read more here.
Keywords: disease; intestinal inflammation; fecal calprotectin; advanced chronic ... See more keywords
High-Fat Diet Consumption Induces Microbiota Dysbiosis and Intestinal Inflammation in Zebrafish
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DOI: 10.1007/s00248-018-1198-9
Abstract: Energy-dense foods and overnutrition represent major starting points altering lipid metabolism, systemic inflammation and gut microbiota. The aim of this work was to investigate the effects of a high-fat diet (HFD) over a period of… read more here.
Keywords: fat diet; intestinal inflammation; inflammation; high fat ... See more keywords
The role of the mucosal barrier system in maintaining gut symbiosis to prevent intestinal inflammation
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DOI: 10.1007/s00281-024-01026-5
Abstract: In the intestinal tract, where numerous intestinal bacteria reside, intestinal epithelial cells produce and release various antimicrobial molecules that form a complex barrier on the mucosal surface. These barrier molecules can be classified into two… read more here.
Keywords: mucosal; intestinal inflammation; barrier; mucosal barrier ... See more keywords
Comparison of volumetric and linear measurements of intestinal inflammation and treatment response in children with newly diagnosed ileal Crohn disease
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DOI: 10.1007/s00330-025-11421-7
Abstract: To compare the responsiveness of linear and volumetric assessments of intestinal inflammation in children with newly diagnosed ileal Crohn disease (CD) into treatment. Twenty children with ileal CD (8 girls; mean age = 14.0 years)… read more here.
Keywords: disease; treatment; intestinal inflammation; treatment response ... See more keywords
Deoxycholic Acid-Induced Gut Dysbiosis Disrupts Bile Acid Enterohepatic Circulation and Promotes Intestinal Inflammation
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DOI: 10.1007/s10620-020-06208-3
Abstract: Background A Western diet is a risk factor for the development of inflammatory bowel disease (IBD). High levels of fecal deoxycholic acid (DCA) in response to a Western diet contribute to bowel inflammatory injury. However,… read more here.
Keywords: dysbiosis; gut dysbiosis; dca; intestinal inflammation ... See more keywords
DHX15 is required to control RNA virus-induced intestinal inflammation
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DOI: 10.1016/j.celrep.2021.109205
Abstract: SUMMARY RNA helicases play critical roles in various biological processes, including serving as viral RNA sensors in innate immunity. Here, we find that RNA helicase DEAH-box helicase 15 (DHX15) is essential for type I interferon… read more here.
Keywords: dhx15; intestinal inflammation; ifn; rna ... See more keywords
The Food Additive Maltodextrin Promotes Endoplasmic Reticulum Stress–Driven Mucus Depletion and Exacerbates Intestinal Inflammation
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DOI: 10.1016/j.jcmgh.2018.09.002
Abstract: Background & Aims Food additives, such as emulsifiers, stabilizers, or bulking agents, are present in the Western diet and their consumption is increasing. However, little is known about their potential effects on intestinal homeostasis. In… read more here.
Keywords: endoplasmic reticulum; intestinal inflammation; inflammation; reticulum stress ... See more keywords
Gut microbiota mediates the protective role of Lactobacillus plantarum in ameliorating deoxynivalenol-induced apoptosis and intestinal inflammation of broiler chickens
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DOI: 10.1016/j.psj.2019.10.034
Abstract: The protection of Lactobacillus plantarum JM113 against deoxynivalenol (DON)-induced apoptosis and intestinal inflammation on the jejunum of broiler chickens and the potential roles of gut microbiota were determined. A total of 144 one-day-old male broilers… read more here.
Keywords: jm113; plantarum; apoptosis intestinal; induced apoptosis ... See more keywords
Paneth cells mediated the response of intestinal stem cells at the early stage of intestinal inflammation in the chicken.
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DOI: 10.1016/j.psj.2020.11.055
Abstract: The rapid renewal and repair of the intestinal mucosa are based on intestinal stem cells (ISC), which are located at the crypt bottom. Paneth cells are an essential component in the crypt, which served as… read more here.
Keywords: hpi; intestinal inflammation; paneth cells; crypt ... See more keywords