Severe Iron Metabolism Defects in Mice With Double Knockout of the Multicopper Ferroxidases Hephaestin and Ceruloplasmin
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2018.06.006
Abstract: Background & Aims Multicopper ferroxidases (MCFs) facilitate intestinal iron absorption and systemic iron recycling, likely by a mechanism involving the oxidization of Fe2+ from the iron exporter ferroportin 1 for delivery to the circulating Fe3+… read more here.
Keywords: multicopper ferroxidases; intestinal iron; mice; iron ... See more keywords
Ferroxidases and Mammalian Iron Homeostasis: Novel Insight Into a Physiological Phenomenon First Described More Than Half a Century Ago
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DOI: 10.1016/j.jcmgh.2018.08.003
Abstract: ntestinal iron absorption is a highly regulated physiIological process that determines overall body iron levels, because humans and other mammals cannot efficiently excrete excess iron. Dietary iron is absorbed mainly by duodenal enterocytes. Iron export… read more here.
Keywords: gastroenterology; iron transport; novel insight; intestinal iron ... See more keywords
Necrotizing enterocolitis and high intestinal iron uptake due to genetic variants
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DOI: 10.1038/pr.2017.195
Abstract: BackgroundIntestinal iron is a nutritional compound, which is essential for enteric microbiota. We evaluated the hypothesis that polymorphisms, which are known modifiers of intestinal iron uptake in adults, are associated with necrotizing enterocolitis (NEC) in… read more here.
Keywords: iron uptake; intestinal iron; necrotizing enterocolitis; iron ... See more keywords
Iron Deficiency Caused by Intestinal Iron Loss—Novel Candidate Genes for Severe Anemia
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DOI: 10.3390/genes12121869
Abstract: The adult human body contains about 4 g of iron. About 1–2 mg of iron is absorbed every day, and in healthy individuals, the same amount is excreted. We describe a patient who presents with… read more here.
Keywords: iron deficiency; iron loss; iron; intestinal iron ... See more keywords
Iron and Zinc Homeostasis and Interactions: Does Enteric Zinc Excretion Cross-Talk with Intestinal Iron Absorption?
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DOI: 10.3390/nu11081885
Abstract: Iron and zinc are essential micronutrients required for growth and health. Deficiencies of these nutrients are highly prevalent among populations, but can be alleviated by supplementation and food fortification. Cross-sectional studies in humans showed positive… read more here.
Keywords: zinc; iron zinc; intestinal iron; iron ... See more keywords