Unveiling the molecular complexity of intestinal ischemia–reperfusion injury through omics technologies
Sign Up to like & getrecommendations! Published in 2024 at "PROTEOMICS"
DOI: 10.1002/pmic.202300160
Abstract: Intestinal ischemia–reperfusion injury (IR) is implicated in various clinical conditions and causes damage to the intestinal epithelium resulting in intestinal barrier loss. This presents a substantial clinical challenge, emphasizing the importance of gaining a comprehensive… read more here.
Keywords: ischemia reperfusion; intestinal ischemia; reperfusion injury; injury ... See more keywords
Acute intestinal ischemia in a patient with COVID-19
Sign Up to like & getrecommendations! Published in 2020 at "Techniques in Coloproctology"
DOI: 10.1007/s10151-020-02255-0
Abstract: A 59-year-old man presented to our hospital with a 10-day history of fever, progressive dyspnoea, and a confirmed diagnosis of bilateral COVID-19 interstitial pneumonia. His past medical history was unremarkable, except for mild hypertension. On… read more here.
Keywords: small bowel; covid; acute intestinal; ischemia ... See more keywords
Gut-Derived Exosomes Mediate Memory Impairment After Intestinal Ischemia/Reperfusion via Activating Microglia.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular neurobiology"
DOI: 10.1007/s12035-021-02444-4
Abstract: Intestinal ischemia/reperfusion is a grave condition with high morbidity and mortality in perioperative and critical care settings and causes multiple organ injuries beyond the intestine, including brain injury. Exosomes act as intercellular communication carriers by… read more here.
Keywords: intestinal exosomes; reperfusion; reperfusion via; intestinal ischemia ... See more keywords
Emerging roles of microRNAs in intestinal ischemia/reperfusion-induced injury: a review.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-020-00772-y
Abstract: Intestinal ischemia/reperfusion (II/R) injury is a serious pathological phenomenon in underlying hemorrhagic shock, trauma, strangulated intestinal obstruction, and acute mesenteric ischemia which associated with high morbidity and mortality. MicroRNAs (miRNAs, miRs) are endogenous non-coding RNAs… read more here.
Keywords: review; ischemia; intestinal ischemia; ischemia reperfusion ... See more keywords
MiR-23a-5p exacerbates intestinal ischemia-reperfusion injury by promoting oxidative stress via targeting PPAR alpha.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2020.114194
Abstract: MiR-23a-5p is involved in the occurrence and development of some serious diseases, but its effects on intestinal ischemia-reperfusion (II/R) injury is unclear. In this research, the hypoxia/reoxygenation (H/R) model on IEC-6 cells and II/R model… read more here.
Keywords: ppar; group; intestinal ischemia; ischemia reperfusion ... See more keywords
Could glucagon-like peptide-1 be a potential biomarker of early-stage intestinal ischemia?
Sign Up to like & getrecommendations! Published in 2019 at "Biochimie"
DOI: 10.1016/j.biochi.2018.11.009
Abstract: Intestinal ischemia, also called mesenteric ischemia, is a severe gastrointestinal and vascular medical emergency caused by a sudden decrease of blood flow through the mesenteric vessels. It generates hypoperfusion of intestinal tissues and can rapidly… read more here.
Keywords: glucagon like; intestinal ischemia; ischemia; early stage ... See more keywords
Nervilifordin F alleviates intestinal ischemia/reperfusion-induced acute lung injury via inhibiting inflammasome and mTOR pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107014
Abstract: Acute lung injury (ALI) is a life-threatening disorder with high rates of morbidity and mortality. Up to now, there are still no effective drugs for its therapies due to the complexity of its etiology and… read more here.
Keywords: mtor pathway; acute lung; mtor; intestinal ischemia ... See more keywords
Deficiency in cold‐inducible RNA‐binding protein attenuates acute respiratory distress syndrome induced by intestinal ischemia‐reperfusion
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DOI: 10.1016/j.surg.2017.06.004
Abstract: Background. Intestinal ischemia‐reperfusion can occur in shock and mesenteric occlusive diseases, causing significant morbidity and mortality. Aside from local injury, intestinal ischemia‐reperfusion can result in remote organ damage, particularly in the lungs. Cold‐inducible RNA‐binding protein… read more here.
Keywords: acute respiratory; reperfusion; intestinal ischemia; ischemia reperfusion ... See more keywords
Inhibition of a triggering receptor expressed on myeloid cells-1 (TREM-1) with an extracellular cold-inducible RNA-binding protein (eCIRP)-derived peptide protects mice from intestinal ischemia-reperfusion injury.
Sign Up to like & getrecommendations! Published in 2020 at "Surgery"
DOI: 10.1016/j.surg.2020.04.010
Abstract: BACKGROUND Intestinal ischemia-reperfusion injury results in morbidity and mortality from both local injury and systemic inflammation and acute lung injury. Extracellular cold-inducible RNA-binding protein is a damage associated molecular pattern that fuels systemic inflammation and… read more here.
Keywords: ischemia; intestinal ischemia; cold inducible; ischemia reperfusion ... See more keywords
The Role of BMP2/4 in Intestinal Ischemia‐Reperfusion Injury: Bridging Smad1/5 and Notch Pathways via Smad6
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.16944
Abstract: Intestinal ischemia‐reperfusion (I/R) injury is a significant clinical problem linked to conditions like acute mesenteric ischemia and intestinal obstruction. This study explores the mechanisms of bone morphogenetic proteins (BMPs)‐Smads and Notch pathways in I/R injury. read more here.
Keywords: ischemia reperfusion; intestinal ischemia; reperfusion injury; injury ... See more keywords
Endothelial Piezo1 stimulates angiogenesis to offer protection against intestinal ischemia–reperfusion injury in mice
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DOI: 10.1186/s10020-025-01197-3
Abstract: Intestinal ischemia–reperfusion (I/R) injury, which occurs in the ileum and not only leads to intestinal tissue damage, but also may trigger systemic inflammatory responses, is a prevalent pathological condition that is typically associated with acute… read more here.
Keywords: ischemia reperfusion; intestinal ischemia; injury; endothelial piezo1 ... See more keywords