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   Articles with "intestinal metaplasia" as a keyword



Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil.

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recommendations! Published in 2022 at "JAMA dermatology"

DOI: 10.1001/jamadermatol.2022.4842

Abstract: This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil. read more here.

Keywords: intestinal metaplasia; intralesional fluorouracil; cutaneous intestinal; adenocarcinoma treated ... See more keywords

Pediatric gastric intestinal metaplasia: The association with Helicobacter pylori and other gastrointestinal diseases.

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recommendations! Published in 2025 at "Journal of pediatric gastroenterology and nutrition"

DOI: 10.1002/jpn3.70037

Abstract: Gastric intestinal metaplasia (GIM) is considered precancerous with Helicobacter pylori (H. pylori) infection being the major risk factor in adults. In pediatric patients, GIM is often an incidental finding, whose long‐term significance is unclear. GIM… read more here.

Keywords: helicobacter pylori; gastric intestinal; intestinal metaplasia; pediatric gastric ... See more keywords
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High-risk individuals for gastric cancer would be missed for surveillance without subtyping of intestinal metaplasia

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recommendations! Published in 2021 at "Virchows Archiv"

DOI: 10.1007/s00428-021-03116-3

Abstract: The use of Operative Link on Gastritis Assessment (OLGA) and Operative Link on Gastritis Assessment based on Intestinal Metaplasia (OLGIM) staging system is recommended for identifying subjects at risk for developing gastric cancer; usually high-risk… read more here.

Keywords: gastric cancer; high risk; risk; intestinal metaplasia ... See more keywords

CDX-2 Expression in Esophageal Biopsies Without Goblet Cell Intestinal Metaplasia May Be Predictive of Barrett’s Esophagus

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recommendations! Published in 2019 at "Digestive Diseases and Sciences"

DOI: 10.1007/s10620-019-05914-x

Abstract: Background CDX-2 is a nuclear homeobox transcription factor not normally expressed in esophageal and gastric epithelia, reported to highlight intestinal metaplasia (IM) in the esophagus. Pathological absence of goblet cells at initial screening via hematoxylin… read more here.

Keywords: intestinal metaplasia; barrett esophagus; goblet; cdx ... See more keywords
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Deoxycholic acid-stimulated macrophage-derived exosomes promote intestinal metaplasia and suppress proliferation in human gastric epithelial cells.

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recommendations! Published in 2020 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2020.173566

Abstract: The crosstalk between macrophages and gastric epithelial cells has emerged as a player in chronic inflammation during intestinal metaplasia. However, the role of bile acid on this modulation remains to be studied. We hypothesized that… read more here.

Keywords: gastric epithelial; intestinal metaplasia; epithelial cells; metaplasia ... See more keywords

TGR5-HNF4α axis contributes to bile acid-induced gastric intestinal metaplasia markers expression

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recommendations! Published in 2020 at "Cell Death Discovery"

DOI: 10.1038/s41420-020-0290-3

Abstract: Intestinal metaplasia (IM) increases the risk of gastric cancer. Our previous results indicated that bile acids (BAs) reflux promotes gastric IM development through kruppel-like factor 4 (KLF4) and caudal-type homeobox 2 (CDX2) activation. However, the… read more here.

Keywords: intestinal metaplasia; hnf4 axis; hnf4; acid ... See more keywords

Single-cell RNA sequencing revealed cell landscape of tongue dorsal mucosa in rats with gastric intestinal metaplasia

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recommendations! Published in 2025 at "Cell Death Discovery"

DOI: 10.1038/s41420-025-02386-z

Abstract: The formation of tongue coating is closely related with the differentiation of the lingual dorsal mucosa, and a great deal of evidence shows that the variation of tongue coating reflects the pathological and physiological state… read more here.

Keywords: dorsal; mucosa; intestinal metaplasia; tongue ... See more keywords

TFF3 initiates gastric intestinal metaplasia by activating JAK2 and STAT3 under high salt conditions

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-09045-4

Abstract: The mechanism underlying the role of trefoil factor family 3 (TFF3) in intestinal metaplasia remains unclear. This study reveals the molecular mechanism by which TFF3, in the process of gastric mucosal epithelial cell intestinal metaplasia… read more here.

Keywords: cdx2; intestinal metaplasia; jak2 stat3; tff3 ... See more keywords

Linked color imaging-based endoscopic grading of gastric intestinal metaplasia and histological gastritis staging in the assessment of gastric cancer risk

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recommendations! Published in 2022 at "Scandinavian Journal of Gastroenterology"

DOI: 10.1080/00365521.2022.2085061

Abstract: Abstract Objective To evaluate the value and compare the effectiveness of linked color imaging-based endoscopic grading of gastric intestinal metaplasia (LCI-EGGIM) and operative link on gastric intestinal metaplasia (OLGIM) in risk stratification of early gastric… read more here.

Keywords: gastric intestinal; egc; risk; lci eggim ... See more keywords
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Caudal type homeoboxes as a driving force in Helicobacter pylori infection-induced gastric intestinal metaplasia

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recommendations! Published in 2020 at "Gut Microbes"

DOI: 10.1080/19490976.2020.1809331

Abstract: ABSTRACT Helicobacter pylori (H. pylori), a common pathogenic bacterium in the stomach, has been demonstrated to be a major cause of gastric cancer (GC). The typical pathological evolution of H. pylori infection-induced GC involves development… read more here.

Keywords: intestinal metaplasia; infection; pylori infection; type ... See more keywords

Deoxycholic acid induces gastric intestinal metaplasia by activating STAT3 signaling and disturbing gastric bile acids metabolism and microbiota

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recommendations! Published in 2022 at "Gut Microbes"

DOI: 10.1080/19490976.2022.2120744

Abstract: ABSTRACT Intestinal metaplasia (IM) is the inevitable precancerous stage to develop intestinal-type gastric cancer (GC). Deoxycholic acid (DCA) is the main bile acid (BA) component of duodenogastric reflux and has shown an increased concentration during… read more here.

Keywords: metabolism; ins gas; deoxycholic acid; dca ... See more keywords