Variable susceptibility of intestinal organoid–derived monolayers to SARS-CoV-2 infection
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1101/2021.07.16.452680
Abstract: Gastrointestinal effects associated with COVID-19 are highly variable for reasons that are not understood. In this study, we used intestinal organoid-derived cultures differentiated from primary human specimens as a model to examine inter-individual variability. Infection… read more here.
Keywords: derived monolayers; intestinal organoid; infection; organoid derived ... See more keywords
A Versatile Human Intestinal Organoid-Derived Epithelial Monolayer Model for the Study of Enteric Pathogens
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00003-21
Abstract: While traditional laboratory techniques and animal models have provided valuable knowledge in discerning virulence mechanisms of enteric pathogens, the complexity of the human gastrointestinal tract has hindered our understanding of physiologically relevant, human-specific interactions and,… read more here.
Keywords: human intestinal; model; human specific; organoid derived ... See more keywords
Establishment of Epithelial Inflammatory Injury Model Using Intestinal Organoid Cultures
Sign Up to like & getrecommendations! Published in 2023 at "Stem Cells International"
DOI: 10.1155/2023/3328655
Abstract: Intestinal epithelial dysfunction is critical in the development of inflammatory bowel disease (IBD). However, most cellular experiments related to epithelial barrier studies in IBD have been based on tumor cell line that lack a variety… read more here.
Keywords: epithelial inflammatory; inflammatory injury; intestinal organoid; model ... See more keywords
Abstract 3870: Validation of a canine intestinal organoid model as a preclinical screen to assess GI toxicity in novel oncology drug development
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DOI: 10.1158/1538-7445.am2018-3870
Abstract: Gastrointestinal (GI) toxicity is a common and often severe dose-limiting side effect of chemotherapy. Symptoms include diarrhea, dehydration and ulceration leading to increased susceptibility to infection, due in part to the damage or loss of… read more here.
Keywords: toxicity; organoid model; novel oncology; intestinal organoid ... See more keywords
A Microwell-Based Intestinal Organoid-Macrophage Co-Culture System to Study Intestinal Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232315364
Abstract: The mammalian intestinal epithelium contains more immune cells than any other tissue, and this is largely because of its constant exposure to pathogens. Macrophages are crucial for maintaining intestinal homeostasis, but they also play a… read more here.
Keywords: system; microwell based; intestinal organoid; based intestinal ... See more keywords