Effects of GBT1118, a voxelotor analog, on intestinal pathophysiology in sickle cell disease.
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DOI: 10.1111/bjh.18813
Abstract: Voxelotor is an allosteric haemoglobin (Hb) modulator that binds covalently and reversibly to Hb alpha chain to facilitate improved Hb-O2 affinity and arterial oxygen. It, therefore, reduces the susceptibility of erythrocytes carrying Haemoglobin S to… read more here.
Keywords: effects gbt1118; voxelotor; intestinal pathophysiology; cell disease ... See more keywords