Intestinal Regeneration: Regulation by the Microenvironment.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.07.009
Abstract: Damage to the intestinal stem cell niche can result from mechanical stress, infections, chronic inflammation or cytotoxic therapies. Progenitor cells can compensate for insults to the stem cell population through dedifferentiation. The microenvironment modulates this… read more here.
Keywords: regulation microenvironment; regeneration regulation; regeneration; intestinal regeneration ... See more keywords
DjRlc is required for the intestinal regeneration in planarian Dugesia japonica.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.07.052
Abstract: The myosin regulatory light chain (RLC) proteins play an important role in cellular processes, especially in muscle contraction. The planarian intestine is a fascinating system for studying the organogenesis during regeneration. In this paper, A… read more here.
Keywords: required intestinal; regeneration; dugesia japonica; djrlc required ... See more keywords
Remodelling of oxygen-transporting tracheoles drives intestinal regeneration and tumorigenesis in Drosophila.
Sign Up to like & getrecommendations! Published in 2021 at "Nature cell biology"
DOI: 10.1038/s41556-021-00674-1
Abstract: The Drosophila trachea, as the functional equivalent of mammalian blood vessels, senses hypoxia and oxygenates the body. Here, we show that the adult intestinal tracheae are dynamic and respond to enteric infection, oxidative agents and… read more here.
Keywords: drosophila; remodelling oxygen; regeneration; damage ... See more keywords
BMP pathway antagonism by Grem1 regulates epithelial cell fate in intestinal regeneration.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.03.052
Abstract: BACKGROUND AND AIMS In homeostasis, intestinal cell fate is controlled by balanced gradients of morphogen signalling. The Bone Morphogenetic Protein (BMP) pathway has a physiological, pro-differentiation role, predominantly inferred through previous experimental pathway inactivation. Intestinal… read more here.
Keywords: bmp pathway; pathway; cell fate; cell ... See more keywords
Single-cell resolution of intestinal regeneration in pythons without crypts illuminates conserved vertebrate regenerative mechanisms
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2405463121
Abstract: Significance The vertebrate intestine is well known for its regenerative capacity, but existing research emphasizes the role of a crypt–villus axis in the constant turnover of the intestinal epithelium. Mechanisms that support large-scale intestinal regeneration… read more here.
Keywords: single cell; cell resolution; intestinal regeneration; resolution intestinal ... See more keywords
JAK/STAT signaling regulated intestinal regeneration defends insect pests against pore-forming toxins produced by Bacillus thuringiensis
Sign Up to like & getrecommendations! Published in 2024 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011823
Abstract: A variety of coordinated host-cell responses are activated as defense mechanisms against pore-forming toxins (PFTs). Bacillus thuringiensis (Bt) is a worldwide used biopesticide whose efficacy and precise application methods limits its use to replace synthetic… read more here.
Keywords: pore forming; intestinal regeneration; stat signaling; jak stat ... See more keywords
Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00112
Abstract: Many echinoderms are regenerative species that exhibit exceptional regenerative capacity, and sea cucumber is a representative organism that could regenerate the whole intestine after evisceration. There are many signaling pathways participate in the regeneration process,… read more here.
Keywords: wnt signaling; sea; regeneration; signaling pathway ... See more keywords
Antibiotics Modulate Intestinal Regeneration
Sign Up to like & getrecommendations! Published in 2021 at "Biology"
DOI: 10.3390/biology10030236
Abstract: Simple Summary The impact of the microbial community on host’s biological functions has uncovered the potential outcomes of antibiotics on host physiology, introducing the caveats of the antibiotic usage. Within animals, the digestive function is… read more here.
Keywords: modulate intestinal; antibiotics modulate; regeneration; effect ... See more keywords
A Review of Histocytological Events and Molecular Mechanisms Involved in Intestine Regeneration in Holothurians
Sign Up to like & getrecommendations! Published in 2022 at "Biology"
DOI: 10.3390/biology11081095
Abstract: Simple Summary Many species of sea cucumber in Echinodermata may eviscerate most of or even all internal organs when encountering predators or adverse environments, and can achieve regeneration within a certain time. Although regeneration time… read more here.
Keywords: regeneration; sea cucumbers; histocytological events; intestinal regeneration ... See more keywords
Chinese Medicine-Derived Natural Compounds and Intestinal Regeneration: Mechanisms and Experimental Evidence
Sign Up to like & getrecommendations! Published in 2025 at "Biomolecules"
DOI: 10.3390/biom15091212
Abstract: Intestinal regeneration is essential for maintaining epithelial integrity and repairing mucosal damage caused by inflammation, infections, or injuries. Traditional Chinese Medicine (TCM) has long utilized herbal remedies for gastrointestinal disorders, and accumulating evidence highlights that… read more here.
Keywords: intestinal regeneration; medicine; natural compounds; chinese medicine ... See more keywords