TNF-α and IL-1β Exposure Modulates the Expression and Functionality of P-Glycoprotein in Intestinal and Renal Barriers.
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DOI: 10.1021/acs.molpharmaceut.2c00140
Abstract: Inflammation is characterized by an increased secretion of proinflammatory cytokines known to alter the expression and functionality of drug transporters. Since P-glycoprotein (P-gp) plays a key role in the pharmacokinetics of several drugs, these modulations… read more here.
Keywords: expression functionality; drug; exposure; intestinal renal ... See more keywords