Heterotrimeric G Stimulatory Protein α Subunit Is Required for Intestinal Smooth Muscle Contraction in Mice.
Sign Up to like & getrecommendations! Published in 2017 at "Gastroenterology"
DOI: 10.1053/j.gastro.2016.12.017
Abstract: BACKGROUND & AIMS The α subunit of the heterotrimeric G stimulatory protein (Gsa), encoded by the guanine nucleotide binding protein, α-stimulating gene (Gnas, in mice), is expressed ubiquitously and mediates receptor-stimulated production of cyclic adenosine monophosphate… read more here.
Keywords: protein; intestinal smooth; muscle; disruption gnas ... See more keywords
Trans-ε-viniferin as an inhibitor of TMEM16A preventing intestinal smooth muscle contraction.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Asian natural products research"
DOI: 10.1080/10286020.2023.2165067
Abstract: TMEM16A regulator is an important tool to study the physiological functions and pathogenesis related to TMEM16A. In the present study, trans-ε-viniferin (TV) was identified as a TMEM16A inhibitor with inhibitory activity against TMEM16A mediated Cl-… read more here.
Keywords: intestinal smooth; trans viniferin; muscle contraction; inhibitor ... See more keywords
Intestinal smooth muscle is required for patterning the enteric nervous system
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Anatomy"
DOI: 10.1111/joa.12583
Abstract: The development of the enteric nervous system (ENS) and intestinal smooth muscle occurs in a spatially and temporally correlated manner, but how they influence each other is unknown. In the developing mid‐gut of the chick… read more here.
Keywords: required patterning; intestinal smooth; muscle; nervous system ... See more keywords
Enhanced Store-Operated Ca2+ Signal of Small Intestinal Smooth Muscle Cells Accelerates Small Bowel Transit Speed in Type 1 Diabetic Mouse
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.691867
Abstract: Aims: The underlying mechanism of diabetic enteropathy, a common complication of type 1 diabetes, remains unclear. Store-operated Ca2+ entry (SOCE) is a ubiquitous type of Ca2+ influx involved in various cellular functions. Here, we show… read more here.
Keywords: transit speed; smooth muscle; intestinal smooth; small intestinal ... See more keywords