Tiny Drosophila intestinal stem cells, big power
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11911
Abstract: The signaling pathways are highly conserved between Drosophila and mammals concerning intestinal development, regeneration, and disease. The powerful genetic tools of Drosophila make it a valuable and convenient alternative to answer basic biological questions that… read more here.
Keywords: intestinal stem; cells big; tiny drosophila; drosophila intestinal ... See more keywords
Environmental Impact on Intestinal Stem Cell Functions in Mucosal Homeostasis and Tumorigenesis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25719
Abstract: Multiple cell compartments at or near the base of the intestinal crypt have been identified as contributing intestinal stem cells for homeostasis of the rapidly turning over intestinal mucosa and cells that can initiate tumor… read more here.
Keywords: homeostasis; cell; intestinal stem; stem cell ... See more keywords
Polyinosinic‐polycytidylic acid accelerates intestinal stem cell proliferation via modulating Myc expression
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29254
Abstract: It is well known that exposure of double‐stranded RNA (dsRNA) to intestine immediately induces villus damage with severe diarrhea, which is mediated by toll‐like receptor 3 signaling activation. However, the role of intestinal stem cells… read more here.
Keywords: polyinosinic polycytidylic; proliferation; poly; intestinal stem ... See more keywords
Chlorogenic acid improves intestinal morphology via enhancing intestinal stem cell activity.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the science of food and agriculture"
DOI: 10.1002/jsfa.12469
Abstract: BACKGROUND Chlorogenic acid (CGA), as one of the most abundant phenolic acids in nature, has been documented to be beneficial for intestinal health. However, the underlying mechanism is still not fully understood. The adult intestinal… read more here.
Keywords: stem cell; intestinal stem; cga; chlorogenic acid ... See more keywords
Lactobacillus salivarius and Lactobacillus agilis feeding regulates intestinal stem cells activity by modulating crypt niche in hens.
Sign Up to like & getrecommendations! Published in 2021 at "Applied microbiology and biotechnology"
DOI: 10.1007/s00253-021-11606-2
Abstract: Previously, we found that Lactobacillus salivarius, Lactobacillus agilis, and Lactobacillus aviarius were associated with excellent egg nutrition in native chicken. Next, the optimal Lactobacillus combination is worth studying. Here, a total of 120 HyLine hens… read more here.
Keywords: crypt; agilis feeding; intestinal stem; cells activity ... See more keywords
The intestinal stem cell regulating gene ASCL2 is required for L1-mediated colon cancer progression.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer letters"
DOI: 10.1016/j.canlet.2018.03.022
Abstract: Aberrant Wnt/β-catenin signaling is a common event during human colorectal cancer (CRC) development. Previously, we characterized members of the L1 family of cell adhesion receptors as targets of β-catenin-LEF1/TCF transactivation that are expressed at the… read more here.
Keywords: ascl2; intestinal stem; stem cell; cancer ... See more keywords
NoxO1 contributes to the differentiation of intestinal stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2017.04.252
Abstract: The intestinal epithelium is one of the most rapidly renewing tissues in the body. Low constitutive ROS formation is needed for cellular differentiation in different tissues. In the intestine, Nox1 is the predominant Nox and… read more here.
Keywords: intestinal stem; stem cells; noxo1 contributes; contributes differentiation ... See more keywords
Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of pharmacological sciences"
DOI: 10.1016/j.jphs.2022.01.002
Abstract: This study aimed to elucidate the role of nitric oxide (NO) in intestinal stem cells in methotrexate-induced ileal mucositis in rats. Methotrexate induced the mRNA expressions of the Wnt/β-catenin target genes Wnt3a, Sox9, and Lgr5… read more here.
Keywords: intestinal stem; methotrexate; wnt catenin; stem cells ... See more keywords
Distinct populations of embryonic epithelial progenitors generate Lgr5+ intestinal stem cells.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.10.012
Abstract: The adult intestinal stem cells (ISCs) are transcriptionally heterogeneous. As the mechanisms governing their developmental specification are still poorly understood, whether this heterogeneity reflects an early determination of distinct cellular sub-types with potentially distinct physiological… read more here.
Keywords: generate lgr5; intestinal stem; embryonic epithelial; epithelial progenitors ... See more keywords
Recombinant Porcine R-Spondin 1 Facilitates Intestinal Stem Cell Expansion along the Crypt-Villus Axis through Potentiating Wnt/β-Catenin Signaling in Homeostasis and Deoxynivalenol Injury.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02013
Abstract: R-spondin 1 (RSPO1) is a ligand for the intestinal stem cell (ISC) marker Lgr5 in the crypt, which functions to amplify canonical Wnt signaling to stimulate the division of ISCs. Despite the crucial role of… read more here.
Keywords: stem cell; intestinal stem; wnt catenin; homeostasis ... See more keywords
Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture
Sign Up to like & getrecommendations! Published in 2017 at "Nature Protocols"
DOI: 10.1038/nprot.2017.095
Abstract: Growing cells within an extracellular matrix-like 3D gel is required for, or can improve, the growth of many cell types ex vivo. Here, we describe a protocol for the generation of well-defined matrices for the… read more here.
Keywords: well defined; formation; intestinal stem; culture ... See more keywords