Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis
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DOI: 10.1038/s41388-019-0816-4
Abstract: The hypoxia-inducible transcription factor HIF-1 is appreciated as a promising target for cancer therapy. However, conditional deletion of HIF-1 and HIF-1 target genes in cells of the tumor microenvironment can result in accelerated tumor growth,… read more here.
Keywords: hif; intestinal tumorigenesis; hif stabilization; tumor ... See more keywords
Nuclear partitioning of Prohibitin 1 inhibits Wnt/β-catenin-dependent intestinal tumorigenesis
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DOI: 10.1038/s41388-020-01538-y
Abstract: The Wnt/β-catenin signaling pathway is aberrantly activated in the majority of colorectal cancer cases due to somatic mutations in the adenomatous polyposis coli ( APC ) gene. Prohibitin 1 (PHB1) serves pleiotropic cellular functions with… read more here.
Keywords: prohibitin; phb1; wnt catenin; intestinal tumorigenesis ... See more keywords
Abstract 4244: Black soybean seed coat extract suppress intestinal tumorigenesis in APCmin mice
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4244
Abstract: Background: Colorectal cancer (CRC) is a major cause of cancer-related deaths in Japan and worldwide. Since CRC has been reported to have close relationship with diet, it seems significant to identify dietary constituents that might… read more here.
Keywords: coat extract; intestinal tumorigenesis; mice; seed ... See more keywords
Emodin Inhibits Inflammation, Carcinogenesis, and Cancer Progression in the AOM/DSS Model of Colitis-Associated Intestinal Tumorigenesis
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DOI: 10.3389/fonc.2020.564674
Abstract: Colorectal cancer (CRC) is one of the most common cancer worldwide. Chronic inflammation contributes to CRC development and progression. Emodin, is a natural anthraquinone derivative with anti-oxidant, anti-inflammatory, and anti-tumor activities. We used the AOM/DSS… read more here.
Keywords: inflammation; associated intestinal; aom dss; cancer ... See more keywords
Chemopreventive effect of 4′-hydroxychalcone on intestinal tumorigenesis in ApcMin mice
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DOI: 10.3892/ol.2021.12474
Abstract: Chalcones and its derivatives are reported to exhibit anti-cancer effects in several cancer cell lines, including colon cancer cells. However, the in vivo anticancer effects and associated mechanisms of chalcones against intestinal tumorigenesis currently remain… read more here.
Keywords: adenomas; colon; colon adenomas; mice ... See more keywords