Regulatory T cells specifically suppress conventional CD8αβ T cells in intestinal tumors of APCMin/+ mice
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-020-02540-9
Abstract: The presence of activated T cells in colorectal cancer tissues is a strong predictor of patient survival. Our previous studies have shown that regulatory T cells (Treg) are able to reduce T cell transendothelial migration… read more here.
Keywords: tcr cd8; cells intestinal; cd8 cells; intestinal tumors ... See more keywords
An adverse outcome pathway for small intestinal tumors in mice involving chronic cytotoxicity and regenerative hyperplasia: a case study with hexavalent chromium, captan, and folpet
Sign Up to like & getrecommendations! Published in 2020 at "Critical Reviews in Toxicology"
DOI: 10.1080/10408444.2020.1823934
Abstract: Abstract Small intestinal (SI) tumors are relatively uncommon outcomes in rodent cancer bioassays, and limited information regarding chemical-induced SI tumorigenesis has been reported in the published literature. Herein, we propose a cytotoxicity-mediated adverse outcome pathway… read more here.
Keywords: adverse outcome; small intestinal; captan folpet; outcome pathway ... See more keywords
Interstitial deletion of the Apc locus in β-catenin-overexpressing cells is a signature of radiation-induced intestinal tumors in C3B6F1 ApcMin/+ mice
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Radiation Research"
DOI: 10.1093/jrr/rrad021
Abstract: Abstract Recent studies have identified interstitial deletions in the cancer genome as a radiation-related mutational signature, although most of them do not fall on cancer driver genes. Pioneering studies in the field have indicated the… read more here.
Keywords: overexpressing cells; radiation induced; radiation; apcmin mice ... See more keywords
Abstract 14: TRAIL inducing small molecule ONC201 prevents intestinal tumors in FAP mouse model
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-14
Abstract: Colorectal cancer (CRC) is a major health problem globally. Preventing CRC in the general population, and especially in high-risk cohorts with colonic polyps, or its recurrence, is a high priority. ONC201, an orally active small… read more here.
Keywords: intestinal tumors; small molecule; mouse model;
Qingchang Wenzhong Decoction Prevents the Occurrence of Intestinal Tumors by Regulating Intestinal Microbiota and Gasdermin E
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.917323
Abstract: Background: Intestinal tumors are the third most common malignant tumors worldwide, accounting for approximately 10% of all new cancer cases worldwide. Cancer prevention is a promising way to limit the intestinal tumor incidence rate; however,… read more here.
Keywords: intestinal microbiota; intestinal tumors; qingchang wenzhong; qcwzd ... See more keywords
Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics
Sign Up to like & getrecommendations! Published in 2022 at "Beilstein Journal of Nanotechnology"
DOI: 10.3762/bjnano.13.115
Abstract: Intestinal cancers are the third most lethal cancers globally, beginning as polyps in the intestine and spreading with a severe metastatic tendency. Chemotherapeutic drugs used in the treatment of intestinal tumors are usually formulated for… read more here.
Keywords: dcx plga; plga; plga nps; drug ... See more keywords