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   Articles with "intimal hyperplasia" as a keyword



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External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery: A Randomized Clinical Trial.

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recommendations! Published in 2022 at "JAMA cardiology"

DOI: 10.1001/jamacardio.2022.1437

Abstract: Importance Intimal hyperplasia and subsequent saphenous vein graft failure may have significant adverse clinical effects in patients undergoing coronary artery bypass surgery. External support of saphenous vein grafts has the potential to prevent vein graft… read more here.

Keywords: saphenous vein; bypass; support; graft ... See more keywords
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Endothelial‐Smooth Muscle Cell Interactions in a Shear‐Exposed Intimal Hyperplasia on‐a‐Dish Model to Evaluate Therapeutic Strategies

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202202317

Abstract: Intimal hyperplasia (IH) represents a major challenge following cardiovascular interventions. While mechanisms are poorly understood, the inefficient preventive methods incentivize the search for novel therapies. A vessel‐on‐a‐dish platform is presented, consisting of direct‐contact cocultures with… read more here.

Keywords: endothelial smooth; intimal hyperplasia; smooth muscle; model ... See more keywords
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2-Methoxyestradiol inhibits carotid artery intimal hyperplasia induced by balloon injury via inhibiting JAK/STAT axis in rats

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recommendations! Published in 2022 at "Environmental Science and Pollution Research"

DOI: 10.1007/s11356-022-19936-y

Abstract: Intimal hyperplasia (IH) is a common complication of vascular interventional procedures that leads to narrowing of the vessel lumen. 2-Methoxyestradiol (2ME), an estrogen metabolite, has numerous pharmacological actions, including vasoprotective and antiproliferative activities. The present… read more here.

Keywords: balloon injury; intimal hyperplasia; jak stat;
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Hydrogen Sulfide-releasing peptide hydrogel limits the development of intimal hyperplasia in human vein segments.

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recommendations! Published in 2019 at "Acta biomaterialia"

DOI: 10.1016/j.actbio.2019.07.042

Abstract: Currently available interventions for vascular occlusive diseases suffer from high failure rates due to re-occlusive vascular wall adaptations, a process called intimal hyperplasia (IH). Naturally occurring hydrogen sulfide (H2S) works as a vasculoprotective gasotransmitter in… read more here.

Keywords: intimal hyperplasia; hydrogel; h2s releasing; vein segments ... See more keywords
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Angiotensin II type 1 receptor-associated protein regulates carotid intimal hyperplasia through controlling apoptosis of vascular smooth muscle cells.

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recommendations! Published in 2018 at "Biochemical and biophysical research communications"

DOI: 10.1016/j.bbrc.2017.12.059

Abstract: Intimal hyperplasia is the main cause of restenosis after carotid artery injury, and the underlying mechanism involves the proliferation and migration of vascular smooth muscle cells (VSMCs). Angiotensin II Type 1 Receptor-Associated Protein (ATRAP) has… read more here.

Keywords: intimal hyperplasia; apoptosis; vascular smooth; muscle cells ... See more keywords
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Nitric oxide releasing nanomatrix gel treatment inhibits venous intimal hyperplasia and improves vascular remodeling in a rodent arteriovenous fistula.

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recommendations! Published in 2021 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2021.121254

Abstract: Vascular access is the lifeline for hemodialysis patients and the single most important component of the hemodialysis procedure. Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis patients, but nearly 60% of AVFs created… read more here.

Keywords: releasing nanomatrix; intimal hyperplasia; nanomatrix gel; avf ... See more keywords
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Sodium thiosulfate acts as a hydrogen sulfide mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerisation

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recommendations! Published in 2022 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2022.103954

Abstract: Summary Background Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularisation. IH is due to vascular smooth muscle cell (VSMC) dedifferentiation, proliferation and migration. The gasotransmitter Hydrogen Sulfide… read more here.

Keywords: hydrogen sulfide; vein segments; human vein; sodium thiosulfate ... See more keywords
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MicroRNA-150 deficiency accelerates intimal hyperplasia by acting as a novel regulator of macrophage polarization.

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recommendations! Published in 2019 at "Life sciences"

DOI: 10.1016/j.lfs.2019.116985

Abstract: BACKGROUND The infiltration and activation of macrophages play key roles in arterial restenosis, providing a promising strategy for the treatment of restenosis caused by intimal hyperplasia. Although miR-150 has been implicated in cardiovascular diseases, the… read more here.

Keywords: 150 deficiency; intimal hyperplasia; mir 150; macrophage ... See more keywords
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Dietary supplementation with Zyflamend poly-herbal extracts and fish oil inhibits intimal hyperplasia development following vascular intervention.

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recommendations! Published in 2019 at "Nutrition research"

DOI: 10.1016/j.nutres.2019.06.001

Abstract: The polyherbal blend Zyflamend™ has been shown to have anti-inflammatory properties and attenuate inflammatory-modulated pathologies. Fish oils have also been shown to have cardioprotective properties. However, the beneficial effects of their combination have not been… read more here.

Keywords: dietary supplementation; zyf wmega; injury; intimal hyperplasia ... See more keywords
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A Human Pluripotent Stem Cell-Based Screen for Smooth Muscle Cell Differentiation and Maturation Identifies Inhibitors of Intimal Hyperplasia

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recommendations! Published in 2019 at "Stem Cell Reports"

DOI: 10.1016/j.stemcr.2019.04.013

Abstract: Summary Contractile to synthetic phenotypic switching of smooth muscle cells (SMCs) contributes to stenosis in vascular disease and vascular transplants. To generate more contractile SMCs, we performed a high-throughput differentiation screen using a MYH11-NLuc-tdTomato human… read more here.

Keywords: intimal hyperplasia; stem cell; differentiation; smooth muscle ... See more keywords

Similar degree of intimal hyperplasia in surgically detected stenotic and nonstenotic arteriovenous fistula segments: a preliminary report

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recommendations! Published in 2018 at "Surgery"

DOI: 10.1016/j.surg.2017.10.038

Abstract: Background. Intimal hyperplasia has been historically associated with improper venous remodeling and stenosis after creation of an arteriovenous fistula. Recently, however, we showed that intimal hyperplasia by itself does not explain the failure of maturation… read more here.

Keywords: intimal hyperplasia; stenotic nonstenotic; stenosis; hyperplasia ... See more keywords