Temporal intra‐host variability of mpox virus genomes in multiple body tissues
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28791
Abstract: Whole‐genome sequencing (WGS) has been widely used for the genomic characterization and the phylogenesis of mpox virus (MPXV) 2022 multi‐country outbreak. To date, no evidence has been reported on intra‐host evolution within samples collected over… read more here.
Keywords: host variability; host; intra host; mpox virus ... See more keywords
Rescuing low frequency variants within intra-host viral populations directly from Oxford Nanopore sequencing data
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-022-28852-1
Abstract: Infectious disease monitoring on Oxford Nanopore Technologies (ONT) platforms offers rapid turnaround times and low cost. Tracking low frequency intra-host variants provides important insights with respect to elucidating within-host viral population dynamics and transmission. However,… read more here.
Keywords: oxford nanopore; host viral; intra host; frequency ... See more keywords
Intra-host evolutionary dynamics of the hepatitis C virus among people who inject drugs
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-88132-8
Abstract: Most individuals chronically infected with hepatitis C virus (HCV) are asymptomatic during the initial stages of infection and therefore the precise timing of infection is often unknown. Retrospective estimation of infection duration would improve existing… read more here.
Keywords: infection; intra host; hcv; hepatitis virus ... See more keywords
Spatio-temporal dynamics of intra-host variability in SARS-CoV-2 genomes
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab1297
Abstract: Abstract During the course of the COVID-19 pandemic, large-scale genome sequencing of SARS-CoV-2 has been useful in tracking its spread and in identifying variants of concern (VOC). Viral and host factors could contribute to variability… read more here.
Keywords: temporal dynamics; sars cov; variability; intra host ... See more keywords
MrHAMER yields highly accurate single molecule viral sequences enabling analysis of intra-host evolution
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab231
Abstract: Abstract Technical challenges remain in the sequencing of RNA viruses due to their high intra-host diversity. This bottleneck is particularly pronounced when interrogating long-range co-evolved genetic interactions given the read-length limitations of next-generation sequencing platforms.… read more here.
Keywords: single molecule; intra host; mrhamer yields; accurate single ... See more keywords
Primary case inference in viral outbreaks through analysis of intra-host variant population
Sign Up to like & getrecommendations! Published in 2022 at "BMC Bioinformatics"
DOI: 10.1186/s12859-022-04585-2
Abstract: Background Investigation of outbreaks to identify the primary case is crucial for the interruption and prevention of transmission of infectious diseases. These individuals may have a higher risk of participating in near future transmission events… read more here.
Keywords: transmission clusters; intra host; case; primary case ... See more keywords
Inter- and intra-host sequence diversity reveal the emergence of viral variants during an overwintering epidemic caused by dengue virus serotype 2 in southern Taiwan
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0006827
Abstract: Purifying selection during dengue viral infection has been suggested as the driving force of viral evolution and the higher complexity of the intra-host quasi-species is thought to offer an adaptive advantage for arboviruses as they… read more here.
Keywords: caused dengue; viral variants; intra host; group ... See more keywords
Mycobacterium tuberculosis Intra-Host Evolution Among Drug-Resistant Tuberculosis Patients Failing Treatment
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Drug Resistance"
DOI: 10.2147/idr.s408976
Abstract: Background Understanding Mycobacterium tuberculosis (Mtb) intra-host evolution of drug resistance is important for successful drug-resistant tuberculosis (DR-TB) treatment and control strategies. This study aimed to characterise the acquisition of genetic mutations and low-frequency variants associated… read more here.
Keywords: tuberculosis; intra host; resistance; treatment ... See more keywords
Rapid SARS-CoV-2 Intra-Host and Within-Household Emergence of Novel Haplotypes
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14020399
Abstract: In February 2020, the municipality of Vo’, a small town near Padua (Italy) was quarantined due to the first coronavirus disease 19 (COVID-19)-related death detected in Italy. To investigate the viral prevalence and clinical features,… read more here.
Keywords: host within; intra host; rapid sars; emergence ... See more keywords