Induced intra- and intermolecular template switching as a therapeutic mechanism against RNA viruses.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular cell"
DOI: 10.1016/j.molcel.2021.10.003
Abstract: Viral RNA-dependent RNA polymerases (RdRps) are a target for broad-spectrum antiviral therapeutic agents. Recently, we demonstrated that incorporation of the T-1106 triphosphate, a pyrazine-carboxamide ribonucleotide, into nascent RNA increases pausing and backtracking by the poliovirus… read more here.
Keywords: intra intermolecular; template switching; pyrazine carboxamide; intermolecular template ... See more keywords
Study of the variation of intra/intermolecular interactions and configuration of a group of Enone anticancer drugs as a result of solvation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2018.10.081
Abstract: Abstract During the last decade, the naturally occurring yellow Enone has drawn considerable attention due to its wide applications in biological, medical and pharmaceutical phenomena. The properties of molecular surrounding media can modify its various… read more here.
Keywords: solvation; intermolecular interactions; intra intermolecular; enone ... See more keywords
MAu2GeS4-Chalcogel (M = Co, Ni): Heterogeneous Intra- and Intermolecular Hydroamination Catalysts.
Sign Up to like & getrecommendations! Published in 2017 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.7b01099
Abstract: High surface area macroporous chalcogenide aerogels (chalcogels) MAu2GeS4 (M = Co, Ni) were prepared from K2Au2GeS4 precursor and Co(OAc)2 or NiCl2 by one-pot sol-gel metathesis reactions in aqueous media. The MAu2GeS4-chalcogels were screened for catalytic… read more here.
Keywords: intra intermolecular; heterogeneous intra; intermolecular hydroamination; mau2ges4 chalcogel ... See more keywords
Intra- vs Intermolecular Cross-Links in Poly(methyl methacrylate) Networks Containing Enamine Bonds
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecules"
DOI: 10.1021/acs.macromol.1c02607
Abstract: The molecular dynamics of a copolymer composed of methyl methacrylate (MMA) and (2-acetoacetoxy)ethyl methacrylate (AEMA) monomers and the influence on it of intra- to intermolecular cross-links of AEMA units with ethylenediamine (EDA) was studied by… read more here.
Keywords: methacrylate; cross linking; intermolecular cross; cross ... See more keywords
Acid-promoted intra- and intermolecular [2+2] cycloaddition of indoles to aryl alkynes to access cyclobutene-fused indolines.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02840a
Abstract: Herein, we have reported the first example of both intra- and intermolecular [2+2] cycloaddition of the electron-rich indoles and unactivated aryl alkynes promoted by the combination of Fe(NO3)3 and HNO3, which highlights efficient and selective… read more here.
Keywords: fused indolines; cyclobutene fused; intermolecular cycloaddition; aryl alkynes ... See more keywords
Revealing Intra- and Intermolecular Interactions Determining Physico-Chemical Features of Selected Quinolone Carboxylic Acid Derivatives
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072299
Abstract: The intra- and intermolecular interactions of selected quinolone carboxylic acid derivatives were studied in monomers, dimers and crystals. The investigated compounds are well-recognized as medicines or as bases for further studies in drug design. We… read more here.
Keywords: carboxylic acid; selected quinolone; quinolone carboxylic; intermolecular interactions ... See more keywords