Early protein restriction increases intra-islet GLP-1 production and pancreatic β-cell proliferation mediated by the β-catenin pathway
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DOI: 10.1007/s00394-020-02192-6
Abstract: Purpose In the present study, we investigated whether intra-islet GLP-1 production and its modulation have a role in apoptosis, proliferation or neogenesis that is compromised by protein restriction during the foetal and suckling periods. Methods… read more here.
Keywords: protein; glp; control; intra islet ... See more keywords
Insulin Secretion Depends on Intra-islet Glucagon Signaling.
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DOI: 10.1016/j.celrep.2018.10.018
Abstract: The intra-islet theory states that glucagon secretion is suppressed when insulin secretion is stimulated, but glucagon's role in intra-islet paracrine regulation is controversial. This study investigated intra-islet functions of glucagon in mice. We examined glucagon-induced insulin… read more here.
Keywords: glucagon; secretion; glp; insulin secretion ... See more keywords
Commentary on “Intra‐islet α‐cell Gs signaling promotes glucagon release”
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DOI: 10.1111/jdi.14317
Abstract: The Gs receptor in pancreatic α cells promotes glucagon transcription and secretion via increasing cAMP. The Gi receptor in pancreatic α cells suppresses glucagon secretion via decreasing cAMP. The Gq receptor in pancreatic α cells… read more here.
Keywords: receptor pancreatic; pancreatic cells; intra islet; commentary intra ... See more keywords