A pipeline for copy number profiling of single circulating tumor cells to assess intra-patient tumor heterogeneity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13174
Abstract: Intra-patient tumor heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess heterogeneity in a minimally invasive manner, methods to perform single circulating tumor cell (CTC) genomics at high resolution are… read more here.
Keywords: tumor; patient tumor; heterogeneity; pipeline ... See more keywords
Exploring the Association Between Intra‐Patient Variability in Trough Concentration of Pazopanib and Clinical Outcomes in Renal Cell Carcinoma and Soft Tissue Sarcoma Patients
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3728
Abstract: Pazopanib is an oral tyrosine kinase inhibitor used in patients with either metastatic renal cell carcinoma or soft tissue sarcoma. Pazopanib has a high interindividual variability in pharmacokinetics and pharmacodynamics and a well‐established exposure–response relationship.… read more here.
Keywords: patient variability; pazopanib; variability; intra patient ... See more keywords
A-SURE: intra-patient comparison of prophylactic effectiveness of a recombinant factor VIII Fc fusion protein versus standard half-life factor VIII in hemophilia A.
Sign Up to like & getrecommendations! Published in 2025 at "Hematology"
DOI: 10.1080/16078454.2025.2513186
Abstract: ABSTRACT Background Despite recent advances, factor replacement therapy remains a cornerstone in hemophilia A treatment. Efmoroctocog alfa, a recombinant FVIII Fc fusion protein (rFVIIIFc), has an extended half-life allowing higher FVIII levels and less frequent… read more here.
Keywords: half life; factor; factor viii; effectiveness ... See more keywords
P966 The intra-patient variability of adalimumab clearance during an intensive sampling study of Crohn’s disease patients receiving maintenance therapy
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjad212.1096
Abstract: Lower adalimumab (ADA) clearance (CL) is associated with improved outcomes in Crohn’s disease (CD) and may be a superior pharmacokinetic (PK) measure than ADA concentrations. We compared intra-patient variability in ADA CL and concentrations within… read more here.
Keywords: patient variability; intra patient; day; ada concentrations ... See more keywords
Tacrolimus Intra-Patient Variability, Time in Therapeutic Range, and Risk of De Novo Donor-Specific Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation"
DOI: 10.1097/tp.0000000000002913
Abstract: BACKGROUND Tacrolimus (TAC) is the most important agent for maintenance immunosuppression and prevention of immunologic injury to the renal allograft, yet there remains no consensus on how best to monitor drug therapy. Both high TAC… read more here.
Keywords: patient variability; risk; variability; tac ... See more keywords
Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2020.2969389
Abstract: In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but… read more here.
Keywords: control oriented; model; patient variations; intra patient ... See more keywords
Treatment of nail psoriasis with calcipotriol/betamethasone dipropionate foam versus pulse dye laser: an unblinded, intra‐patient, left‐to‐right prospective study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16426
Abstract: Combination of topical vitamin D3 analogues and corticosteroids is a valid therapeutic option for nail psoriasis.1-3 Pulsed dye laser (PDL) has also been employed with variable success.4-9 This single-center, intra-patient (left vs. right) prospective study… read more here.
Keywords: left right; patient left; dye laser; psoriasis ... See more keywords
Intra‐patient variability in tacrolimus exposure in pediatric liver transplant recipients: Evolution, risk factors, and impact on patient outcomes
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Transplantation"
DOI: 10.1111/petr.13388
Abstract: This study aims to investigate the evolution and factors associated with TAC IPV and its impact on patient outcomes in pediatric LT recipients. read more here.
Keywords: evolution; impact patient; patient outcomes; variability tacrolimus ... See more keywords
Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1186/s13148-019-0775-1
Abstract: BackgroundUntil today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may in part be explained by data from preclinical… read more here.
Keywords: escalation; patient dose; intra patient; dose escalation ... See more keywords
Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.
Sign Up to like & getrecommendations! Published in 2019 at "Acta dermato-venereologica"
DOI: 10.2340/00015555-3382
Abstract: Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30… read more here.
Keywords: braf nras; patient heterogeneity; heterogeneity braf; intra patient ... See more keywords
Case Study: Intra-Patient Heterogeneity of Aneurysmal Tissue Properties
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2018.00082
Abstract: Introduction: Current recommendations for surgical treatment of abdominal aortic aneurysms (AAAs) rely on the assessment of aortic diameter as a marker for risk of rupture. The use of aortic size alone may overlook the role… read more here.
Keywords: heterogeneity aneurysmal; heterogeneity; patient heterogeneity; tissue ... See more keywords