A pipeline for copy number profiling of single circulating tumor cells to assess intra-patient tumor heterogeneity.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13174
Abstract: Intra-patient tumor heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess heterogeneity in a minimally invasive manner, methods to perform single circulating tumor cell (CTC) genomics at high resolution are… read more here.
Keywords: tumor; patient tumor; heterogeneity; pipeline ... See more keywords
Tacrolimus Intra-Patient Variability, Time in Therapeutic Range, and Risk of De Novo Donor-Specific Antibodies.
Sign Up to like & getrecommendations! Published in 2019 at "Transplantation"
DOI: 10.1097/tp.0000000000002913
Abstract: BACKGROUND Tacrolimus (TAC) is the most important agent for maintenance immunosuppression and prevention of immunologic injury to the renal allograft, yet there remains no consensus on how best to monitor drug therapy. Both high TAC… read more here.
Keywords: patient variability; risk; variability; tac ... See more keywords
Control-Oriented Model With Intra-Patient Variations for an Artificial Pancreas
Sign Up to like & getrecommendations! Published in 2020 at "IEEE Journal of Biomedical and Health Informatics"
DOI: 10.1109/jbhi.2020.2969389
Abstract: In this work, a low-order model designed for glucose regulation in Type 1 Diabetes Mellitus (T1DM) is obtained from the UVA/Padova metabolic simulator. It captures not only the nonlinear behavior of the glucose-insulin system, but… read more here.
Keywords: control oriented; model; patient variations; intra patient ... See more keywords
Treatment of nail psoriasis with calcipotriol/betamethasone dipropionate foam versus pulse dye laser: an unblinded, intra‐patient, left‐to‐right prospective study
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the European Academy of Dermatology and Venereology"
DOI: 10.1111/jdv.16426
Abstract: Combination of topical vitamin D3 analogues and corticosteroids is a valid therapeutic option for nail psoriasis.1-3 Pulsed dye laser (PDL) has also been employed with variable success.4-9 This single-center, intra-patient (left vs. right) prospective study… read more here.
Keywords: left right; patient left; dye laser; psoriasis ... See more keywords
Intra‐patient variability in tacrolimus exposure in pediatric liver transplant recipients: Evolution, risk factors, and impact on patient outcomes
Sign Up to like & getrecommendations! Published in 2019 at "Pediatric Transplantation"
DOI: 10.1111/petr.13388
Abstract: This study aims to investigate the evolution and factors associated with TAC IPV and its impact on patient outcomes in pediatric LT recipients. read more here.
Keywords: evolution; impact patient; patient outcomes; variability tacrolimus ... See more keywords
Phase I/II intra-patient dose escalation study of vorinostat in children with relapsed solid tumor, lymphoma, or leukemia
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Epigenetics"
DOI: 10.1186/s13148-019-0775-1
Abstract: BackgroundUntil today, adult and pediatric clinical trials investigating single-agent or combinatorial HDAC inhibitors including vorinostat in solid tumors have largely failed to demonstrate efficacy. These results may in part be explained by data from preclinical… read more here.
Keywords: escalation; patient dose; intra patient; dose escalation ... See more keywords
Intra-patient Heterogeneity of BRAF and NRAS Molecular Alterations in Primary Melanoma and Metastases.
Sign Up to like & getrecommendations! Published in 2019 at "Acta dermato-venereologica"
DOI: 10.2340/00015555-3382
Abstract: Mutations in MAPK signalling genes are driver events in melanoma, and have therapeutic relevance in the metastatic and adjuvant setting. This study evaluated the intra-patient heterogeneity of BRAF, NRAS and c-KIT mutational status between 30… read more here.
Keywords: braf nras; patient heterogeneity; heterogeneity braf; intra patient ... See more keywords
Case Study: Intra-Patient Heterogeneity of Aneurysmal Tissue Properties
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2018.00082
Abstract: Introduction: Current recommendations for surgical treatment of abdominal aortic aneurysms (AAAs) rely on the assessment of aortic diameter as a marker for risk of rupture. The use of aortic size alone may overlook the role… read more here.
Keywords: heterogeneity aneurysmal; heterogeneity; patient heterogeneity; tissue ... See more keywords
Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.855463
Abstract: Introduction The mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood. Objective We evaluate the potential translational implications of intra-patient… read more here.
Keywords: liver metastasis; heterogeneity; patient heterogeneity; oncology ... See more keywords
Comparison of different methods to assess tacrolimus concentration intra-patient variability as potential marker of medication non-adherence
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.973564
Abstract: Background and objective: Non-adherence to tacrolimus commonly manifests as low drug concentrations and/or high intra-patient variability (IPV) of concentrations across multiple measurements. We aimed to compare several methods of tacrolimus IPV calculation and evaluate how… read more here.
Keywords: adherence; intra patient; variability; non adherence ... See more keywords
The Role of Intra-Patient Variability of Tacrolimus Drug Concentrations in Solid Organ Transplantation: A Focus on Liver, Heart, Lung and Pancreas
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14020379
Abstract: Tacrolimus, the keystone immunosuppressive drug administered after solid organ transplantation, presents a narrow therapeutic index and wide inter- and intra-patient pharmacokinetic variability (IPV). The latter has been fairly studied in kidney transplantation, where it could… read more here.
Keywords: organ transplantation; intra patient; transplantation; liver heart ... See more keywords