Untargeted Metabolomic Characterization of Glioblastoma Intra-Tumor Heterogeneity Using OrbiSIMS
Sign Up to like & getrecommendations! Published in 2023 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c05807
Abstract: Glioblastoma (GBM) is an incurable brain cancer with a median survival of less than two years from diagnosis. The standard treatment of GBM is multimodality therapy comprising surgical resection, radiation, and chemotherapy. However, prognosis remains… read more here.
Keywords: tumor heterogeneity; gbm; tumor; intra tumor ... See more keywords
Abstract 3316: Intra-tumor heterogeneity assessment of liver lesions for colorectal cancer patients on CT-scans
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3316
Abstract: The objective is to find a consensus definition of intra-tumor heterogeneity of liver lesions for colorectal cancer patients on computed tomography (CT) scans and to evaluate the prognostic value of the newly defined criteria. 89… read more here.
Keywords: tumor heterogeneity; heterogeneity; liver lesions; tumor ... See more keywords
Abstract 5927: Leveraging single cell RNA profiling to uncover intra-tumor heterogeneity across cytogenetic subgroups in acute myeloid leukemia
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5927
Abstract: Acute Myeloid Leukemia (AML) is a heterogenous disease characterized by immature blasts at different states of differentiation resulting in marked intra-tumor heterogeneity (ITH). Compared to patients with diploid cytogenetics, deletions in chromosome 7/7q (del7/7q), 5/5q… read more here.
Keywords: tumor heterogeneity; cell; myeloid leukemia; aml cells ... See more keywords
Inter and intra-tumor heterogeneity of PD-L1 and MET expression in metastatic renal cell carcinoma (mRCC).
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.4569
Abstract: 4569Background: Although inhibition of PD-1/PD-L1 and MET receptors have clinical efficacy in mRCC, their expression is not a predictive biomarker. Heterogeneity between the sites of disease might ... read more here.
Keywords: heterogeneity met; heterogeneity; intra tumor; inter intra ... See more keywords
Expression of CD133 and CD44 in glioblastoma stem cells correlates with cell proliferation, phenotype stability and intra-tumor heterogeneity
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0172791
Abstract: Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently… read more here.
Keywords: cd133 cd44; intra tumor; cd44; expression ... See more keywords
Mutation landscape and intra-tumor heterogeneity of two MANECs of the esophagus revealed by multi-region sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18678
Abstract: Mixed adenoneuroendocrine carcinoma (MANEC) in the esophagus is an infrequent but highly malignant cancer with few known genomic alterations. We conducted whole-exome sequencing and whole-genome SNP genotyping for 4-6 tumor subregions and 5-6 adjacent normal… read more here.
Keywords: tumor; mutation landscape; heterogeneity; intra tumor ... See more keywords
Computational Methods for Characterizing Cancer Mutational Heterogeneity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2017.00083
Abstract: Advances in DNA sequencing technologies have allowed the characterization of somatic mutations in a large number of cancer genomes at an unprecedented level of detail, revealing the extreme genetic heterogeneity of cancer at two different… read more here.
Keywords: heterogeneity; intra tumor; computational methods; cancer ... See more keywords
From Chemotherapy to Combined Targeted Therapeutics: In Vitro and in Vivo Models to Decipher Intra-tumor Heterogeneity
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00077
Abstract: Recent advances in next-generation sequencing and other omics technologies capable to map cell fate provide increasing evidence on the crucial role of intra-tumor heterogeneity (ITH) for cancer progression. The different facets of ITH, from genomic… read more here.
Keywords: vitro vivo; heterogeneity; intra tumor; vivo models ... See more keywords
Intra-Tumor Heterogeneity Revealed by Mass Spectrometry Imaging Is Associated with the Prognosis of Breast Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13174349
Abstract: Simple Summary The coexistence of genetically distinct cancer cell clones, their phenotypic plasticity, and the presence of different constituents of the tumor microenvironment create intra-tumor heterogeneity, which affects cancer development and its response to therapy.… read more here.
Keywords: heterogeneity; intra tumor; heterogeneity revealed; cancer ... See more keywords
Together Intra-Tumor Hypoxia and Macrophagic Immunity Are Driven Worst Outcome in Pediatric High-Grade Osteosarcomas
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14061482
Abstract: Simple Summary Radiological and immunohistochemical data were correlated with the outcome in a retrospective monocentric cohort of 30 pediatric osteosarcomas (OTS). A necrotic volume of more than 50 cm3 at diagnosis was significantly linked to… read more here.
Keywords: tumor hypoxia; survival; caix; volume ... See more keywords