Methodological Advancements for Investigating Intra-tumoral Heterogeneity in Breast Cancer at the Bench and Bedside
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Mammary Gland Biology and Neoplasia"
DOI: 10.1007/s10911-020-09470-3
Abstract: There is a major need to overcome therapeutic resistance and metastasis that eventually arises in many breast cancer patients. Therapy resistant and metastatic tumors are increasingly recognized to possess intra-tumoral heterogeneity (ITH), a diversity of… read more here.
Keywords: cancer; tumoral heterogeneity; intra tumoral; breast cancer ... See more keywords
Single-cell transcriptomics reveals the landscape of intra-tumoral heterogeneity and stemness-related subpopulations in liver cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.06.002
Abstract: Hepatocellular carcinoma (HCC) is heterogeneous, rendering its current curative treatments ineffective. The emergence of single-cell genomics represents a powerful strategy in delineating the complex molecular landscapes of cancers. In this study, we demonstrated the feasibility… read more here.
Keywords: single cell; stemness related; heterogeneity; cancer ... See more keywords
Preoperative Grading of Glioma Using Dynamic Susceptibility Contrast MRI: Relative Cerebral Blood Volume Analysis of Intra-tumoural and Peri-tumoural Tissue
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Neurology and Neurosurgery"
DOI: 10.1016/j.clineuro.2018.01.003
Abstract: OBJECTIVES To assess the usefulness of intra-tumor and peri-tumoral relative cerebral blood volume (rCBV) in preoperative glioma grading. PATIENTS AND METHODS 21 patients with histopathologically confirmed glioma were included. Imaging was achieved on a 1.5T… read more here.
Keywords: glioma; peri tumoral; peri; rcbv ... See more keywords
Antitumoral effect and reduced systemic toxicity in mice after intra‐tumoral injection of an in vivo solidifying calcium sulfate formulation with docetaxel
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmaceutics and Biopharmaceutics"
DOI: 10.1016/j.ejpb.2017.01.018
Abstract: Background: Docetaxel is a cytostatic agent approved for treatment of non‐small cell lung cancer as well as other cancers. Although docetaxel is an effective cytostatic agent, its effectiveness in clinical practice is associated with a… read more here.
Keywords: calcium sulfate; reduced systemic; formulation; intra tumoral ... See more keywords
Efficacy of paclitaxel/dexamethasone intra‐tumoral delivery in treating orthotopic mouse breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.04.010
Abstract: ABSTRACT The effect of topical co‐administration of promoter drugs with paclitaxel to increase anti‐tumor effects of paclitaxel was investigated. Mice with orthotopic 4T1‐Luc breast cancer received single intra‐tumoral injection of a polymeric formulation with paclitaxel… read more here.
Keywords: breast cancer; promoter; cancer; dexamethasone ... See more keywords
Thermosensitive nanocomposite gel for intra‐tumoral two‐photon photodynamic therapy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2019.01.019
Abstract: Abstract We propose here a new approach to achieve intratumoral near‐infrared (NIR) two‐photon photodynamic therapy (PDT). We established a composite micellar thermosensitive hydrogel made of clinically approved methoxy poly(ethylene glycol)‐polylactide copolymer (mPEG‐PDLLA) and Pluronic (F127).… read more here.
Keywords: photodynamic therapy; two photon; photon photodynamic; rheology ... See more keywords
Evaluating angioarchitectural characteristics of glial and metastatic brain tumors with conventional magnetic resonance imaging
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2020.04.051
Abstract: Primary and metastatic brain tumors can overlap in traditional imaging features detected on preoperative conventional magnetic resonance imaging (MRI). The research objective was to determine whether morphological vascular characteristics present in routine preoperative imaging using… read more here.
Keywords: conventional magnetic; magnetic resonance; metastatic brain; intra tumoral ... See more keywords
Topographic mapping of the glioblastoma proteome reveals a triple-axis model of intra-tumoral heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Nature Communications"
DOI: 10.1038/s41467-021-27667-w
Abstract: Glioblastoma is an aggressive form of brain cancer with well-established patterns of intra-tumoral heterogeneity implicated in treatment resistance and progression. While regional and single cell transcriptomic variations of glioblastoma have been recently resolved, downstream phenotype-level… read more here.
Keywords: glioblastoma; heterogeneity; model intra; tumoral heterogeneity ... See more keywords
Prospective prediction of plasma pharmacokinetics of a novel immune-modulating agent in cancer patients after intra-tumoral administration: translation from non-clinical species to humans
Sign Up to like & getrecommendations! Published in 2021 at "Xenobiotica"
DOI: 10.1080/00498254.2021.1934606
Abstract: Abstract Intra-tumoral (I-TUMOUR) delivery is being widely explored for novel anti-cancer agents. This route is anticipated to result in high tumour concentrations leading to better efficacy and safety. Prediction of human systemic pharmacokinetics (PK) from… read more here.
Keywords: cancer; tumour; prediction; non clinical ... See more keywords
Spatially-resolved single-cell assessment of pancreatic cancer expression subtypes reveals co-expressor phenotypes and extensive intra-tumoral heterogeneity.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3050
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has been classified into classical and basal-like transcriptional subtypes by bulk RNA measurements. However, recent work has uncovered greater complexity to transcriptional subtypes than was initially appreciated using bulk RNA expression… read more here.
Keywords: intra tumoral; cell; heterogeneity; expression ... See more keywords
Abstract 6691: Delivering intra-tumoral immune modulators and targeting cancer stem cells using recombinant- AAVs
Sign Up to like & getrecommendations! Published in 2020 at "Immunology"
DOI: 10.1158/1538-7445.am2020-6691
Abstract: Solid tumors are composed of heterogeneous cell populations that support rapid growth of cancer cells and suppress immune cell responses. Unleashing the body9s own immune response to eradicate cancer cells is one of the most… read more here.
Keywords: cancer stem; cell; cancer; stem cells ... See more keywords