Production of afucosylated antibodies in CHO cells by coexpression of an anti‐FUT8 intrabody
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28127
Abstract: Some effector functions prompted by immunoglobulin G (IgG) antibodies, such as antibody‐dependent cell‐mediated cytotoxicity (ADCC), strongly depend on the N‐glycans linked to asparagine 297 of the Fc region of the protein. A single α‐(1,6)‐fucosyltransferase (FUT8)… read more here.
Keywords: fut8 intrabody; production; anti fut8; intrabody ... See more keywords
In vitro affinity maturation to improve the efficacy of a hypoxia-inducible factor 1α single-domain intrabody.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.097
Abstract: Affinity is an important property of therapeutic antibodies, so improving affinity is critical to the biological activity and clinical efficacy. An anti-HIF-1α nanobody, VHH212, was screened via a native ribosome display library with a 26.6 nM… read more here.
Keywords: intrabody; vitro affinity; maturation improve; affinity ... See more keywords
Lipid nanoparticle-delivered intrabodies for inhibiting necroptosis and pyroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Biochemical Journal"
DOI: 10.1042/bcj20253191
Abstract: Intrabodies are intracellularly expressed high-affinity protein binders such as nanobodies and monobodies that offer an alternative approach to small molecules. However, the maturation of intrabody technology into new therapeutic modalities has been limited by the… read more here.
Keywords: necroptosis pyroptosis; intrabody; delivery; protein ... See more keywords
Data Packet Transmission Through Fat Tissue for Wireless IntraBody Networks
Sign Up to like & getrecommendations! Published in 2017 at "IEEE Journal of Electromagnetics, RF and Microwaves in Medicine and Biology"
DOI: 10.1109/jerm.2017.2766561
Abstract: This paper explores high data rate microwave communication through fat tissue in order to address the wide bandwidth requirements of intrabody area networks. We have designed and carried out experiments on an IEEE 802.15.4-based WBAN… read more here.
Keywords: intrabody; data packet; high data; fat tissue ... See more keywords
Intrabody-Induced Cell Death by Targeting the T. brucei Cytoskeletal Protein TbBILBO1
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.00915-21
Abstract: Trypanosoma brucei belongs to a group of important zoonotic parasites. We investigated how these organisms develop their cytoskeleton (the internal skeleton that controls cell shape) and focused on an essential protein (BILBO1) first described in… read more here.
Keywords: intrabody; brucei belongs; trypanosoma brucei; tbbilbo1 ... See more keywords
Selection and Modelling of a New Single-Domain Intrabody Against TDP-43
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.773234
Abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder associated to deteriorating motor and cognitive functions, and short survival. The disease is caused by neuronal death which results in progressive muscle wasting and weakness, ultimately leading… read more here.
Keywords: intrabody tdp; modelling new; intrabody; selection modelling ... See more keywords