Acid-Induced Intracellular Dissociation of β-Cyclodextrin-Threaded Polyrotaxanes Directed toward Attenuating Phototoxicity of Bisretinoids through Promoting Excretion.
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DOI: 10.1021/acs.molpharmaceut.7b00859
Abstract: In the retinal pigment epithelium of patients with age-related macular degeneration (AMD), excess N-retinylidene-N-retinylethanolamine (A2E), a dimer of all-trans-retinal, accumulats to induce inflammatory cytokine secretion and phototoxic effects. Therefore, the reduction of intracellular A2E is… read more here.
Keywords: threaded polyrotaxanes; cyclodextrin threaded; acid labile; prxs ... See more keywords