Intracellular Absolute Quantification of Oligonucleotide Therapeutics by NanoSIMS.
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DOI: 10.1021/acs.analchem.2c02111
Abstract: Antisense oligonucleotide (ASO)-based therapeutics hold great potential for the treatment of a variety of diseases. Therefore, a better understanding of cellular delivery, uptake, and trafficking mechanisms of ASOs is highly important for early-stage drug discovery.… read more here.
Keywords: quantification oligonucleotide; quantification; intracellular absolute; aso ... See more keywords