Intracellular accumulation and DNA damage caused by methylmercury in glial cells
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23170
Abstract: Mercury is widely used in industrial and extractive processes, and the improper disposal of waste or products containing this metal produces a significant impact on ecosystems, causing adverse effects on living organisms, including humans. Exposure… read more here.
Keywords: dna; damage; methylmercury; glial cells ... See more keywords
Quantification of Intracellular Accumulation and Retention of Lysosomotropic Macrocyclic Compounds by High-Throughput Imaging of Lysosomal Changes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.11.001
Abstract: Many marketed pharmaceuticals reach extremely high tissue concentrations due to accumulation in lysosomes (lysosomotropism). Quantitative prediction of intracellular concentrations of accumulating drugs is challenging, especially for macrocyclic compounds that mainly do not fit in current… read more here.
Keywords: macrocyclic compounds; intracellular accumulation; accumulation; throughput imaging ... See more keywords
Intracellular accumulation and immunological responses of lipid modified magnetic iron nanoparticles in mouse antigen processing cells.
Sign Up to like & getrecommendations! Published in 2017 at "Biomaterials science"
DOI: 10.1039/c7bm00244k
Abstract: Understanding the effects of magnetic iron nanoparticles (MINPs) on the immune response is vitally important for biomedical applications such as cancer therapy, disease diagnosis and novel cancer imaging. In this study, lipid modified MINPs were… read more here.
Keywords: intracellular accumulation; antigen processing; lipid modified; minps ... See more keywords
Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutic Drug Monitoring"
DOI: 10.1097/ftd.0000000000001043
Abstract: Supplemental Digital Content is Available in the Text. Background: Although atorvastatin (ATV) is well-tolerated, patients may report muscle complaints. These are difficult to predict owing to high interindividual variability. Such side effects are linked to… read more here.
Keywords: slco2b1 abcc1; atv; accumulation; intracellular accumulation ... See more keywords
Functional Diversity of Gram-Negative Permeability Barriers Reflected in Antibacterial Activities and Intracellular Accumulation of Antibiotics
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.01377-22
Abstract: Gram-negative bacteria are notoriously more resistant to antibiotics than Gram-positive bacteria, primarily due to the presence of the outer membrane and a plethora of active efflux pumps. However, the potency of antibiotics also varies dramatically… read more here.
Keywords: intracellular accumulation; antibacterial activities; permeability barriers; gram negative ... See more keywords
Basigin drives intracellular accumulation of l-lactate by harvesting protons and substrate anions
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0249110
Abstract: Transmembrane transport of l-lactate by members of the monocarboxylate transporter family, MCT, is vital in human physiology and a malignancy factor in cancer. Interaction with an accessory protein, typically basigin, is required to deliver the… read more here.
Keywords: intracellular accumulation; protons substrate; substrate anions; lactate ... See more keywords
Synergy of surface adsorption and intracellular accumulation for removal of uranium with Stenotrophomonas sp: Performance and mechanisms.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental research"
DOI: 10.2139/ssrn.4280146
Abstract: Uranium is well-known to have serious adverse effects on the ecological environment and human health. Bioremediation stands out among many remediation methods owing to its being economically feasible and environmentally friendly. This study reported a… read more here.
Keywords: adsorption; adsorption intracellular; surface adsorption; uranium stenotrophomonas ... See more keywords
Aβ Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of Aβ42 Through Go/Gβγ Signaling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.852738
Abstract: Alzheimer’s disease (AD) is characterized by the deposition of aggregated species of amyloid beta (Aβ) in the brain, which leads to progressive cognitive deficits and dementia. Aβ is generated by the successive cleavage of the… read more here.
Keywords: processing app; app intracellular; app; amyloidogenic processing ... See more keywords
Accum™ Technology: A Novel Conjugable Primer for Onco-Immunotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123807
Abstract: Compromised activity is a common impediment for biologics requiring endosome trafficking into target cells. In cancer cells, antibody-drug conjugates (ADCs) are trapped in endosomes or subsequently pumped extracellularly, leading to a reduction in intracellular accumulation.… read more here.
Keywords: novel conjugable; immunotherapy; onco immunotherapy; accum technology ... See more keywords
Evaluation of the intracellular accumulation of fluoroquinolones in mycobacteria by fluorometric assays
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Mycobacteriology"
DOI: 10.4103/ijmy.ijmy_194_19
Abstract: Background: Fluoroquinolones (FQs) are being used as second-line agents in the treatment of tuberculosis caused by multidrug-resistant strains. Ofloxacin (OFX) is being tried as a part of modified multidrug therapy regimens for leprosy. A preliminary… read more here.
Keywords: intracellular accumulation; cif; accumulation; accumulation fluoroquinolones ... See more keywords