Protease-responsive mass barcoded nanotranslators for simultaneously quantifying the intracellular activity of cascaded caspases in apoptosis pathwaysâ€
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DOI: 10.1039/d0sc01534b
Abstract: Quantitatively delineating the activation network of multiple proteases that participate in cellular processes is highly essential for understanding the physiological and pathological states of cells. In this study, protease-responsive mass barcoded nanotranslators (PRMNTs) were engineered… read more here.
Keywords: intracellular activity; apoptosis; mass; responsive mass ... See more keywords
Intracellular activity of antimicrobial compounds used for Staphylococcus aureus nasal decolonization
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DOI: 10.1093/jac/dky318
Abstract: Background Staphylococcus aureus is able to invade mammalian cells during infection and was recently observed inside nasal mucosa of healthy carriers. Objectives To determine the intracellular activity of antimicrobial compounds used for decolonization procedures using… read more here.
Keywords: antimicrobial compounds; intracellular activity; decolonization; aureus ... See more keywords
Intracellular Activity of Antibiotics against Coxiella burnetii in a Model of Activated Human THP-1 Cells
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DOI: 10.1128/aac.01061-21
Abstract: We evaluated antibiotic activity against the intracellular bacterium Coxiella burnetii using an activated THP-1 cell model of infection. At clinically relevant concentrations, the intracellular bacterial load was reduced 300-fold by levofloxacin and finafloxacin, 40-fold by… read more here.
Keywords: thp; antibiotic activity; activity; intracellular activity ... See more keywords