Intracellular amyloid-β disrupts tight junctions of the retinal pigment epithelium via NF-κB activation
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.07.013
Abstract: Drusen are focal deposits between the retinal pigment epithelium (RPE) and Bruch's membrane in the retina of patients with age-related macular degeneration. Amyloid-β is one of the important components of drusen, which leads to local… read more here.
Keywords: intracellular amyloid; amyloid; pigment epithelium; tight junctions ... See more keywords
Intracellular Amyloid-β Detection from Human Brain Sections Using a Microfluidic Immunoassay in Tandem with MALDI-MS.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03825
Abstract: Alzheimer's disease (AD) currently affects more than 30 million people worldwide. The lack of understanding of AD's physiopathology limits the development of therapeutic and diagnostic tools. Soluble amyloid-β peptide (Aβ) oligomers that appear as intermediates… read more here.
Keywords: intracellular amyloid; brain; human brain; amyloid detection ... See more keywords
Role of Intracellular Amyloid β as Pathway Modulator, Biomarker, and Therapy Target
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23094656
Abstract: The β- and γ-secretase-driven cleavage of the amyloid precursor protein (APP) gives rise to the amyloid β peptide, which is believed to be the main driver of neurodegeneration in Alzheimer’s disease (AD). As it is… read more here.
Keywords: pathway modulator; modulator biomarker; role; intracellular amyloid ... See more keywords