Cascade-targeting Poly(amino acid) Nanoparticles Eliminate Intracellular Bacteria via on-site Antibiotic Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "Advanced materials"
DOI: 10.1002/adma.202109789
Abstract: Intracellular bacteria in latent or dormant states tolerate high-dose antibiotics. Fighting against these opportunistic bacteria has been a long-standing challenge. Herein, we design a cascade-targeting drug delivery system (DDS) that can sequentially target macrophages and… read more here.
Keywords: cascade targeting; fam nps; intracellular bacteria; rif fam ... See more keywords
First Evidence of Intracellular Bacteria Cardinium in Thermophilic Mite Microzetorchestes emeryi (Acari: Oribatida): Molecular Screening of Bacterial Endosymbiont Species
Sign Up to like & getrecommendations! Published in 2019 at "Current Microbiology"
DOI: 10.1007/s00284-019-01717-5
Abstract: We undertook the issue of the distribution of intracellular bacteria among Oribatida (Acari). Six genera of bacteria were detected by PCR and Sanger DNA sequencing: Wolbachia, Cardinium, Rickettsia, Spiroplasma, Arsenophonus, and Hamiltonella. Our research, for… read more here.
Keywords: intracellular bacteria; evidence intracellular; first evidence; cardinium thermophilic ... See more keywords
Molecular investigation of zoonotic intracellular bacteria in Chilean bats.
Sign Up to like & getrecommendations! Published in 2020 at "Comparative immunology, microbiology and infectious diseases"
DOI: 10.1016/j.cimid.2020.101541
Abstract: Intracellular pathogens were investigated for the first time in 55 Chilean bats belonging to six species. Using a conventional PCR protocol targeting a fragment of the ITS region, 21 bats (38 %) were positive for… read more here.
Keywords: molecular investigation; intracellular bacteria; chilean bats; investigation zoonotic ... See more keywords
Engineering of obligate intracellular bacteria: progress, challenges and paradigms
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Microbiology"
DOI: 10.1038/nrmicro.2017.59
Abstract: It is estimated that approximately one billion people are at risk of infection with obligate intracellular bacteria, but little is known about the underlying mechanisms that govern their life cycles. The difficulty in studying Chlamydia… read more here.
Keywords: engineering obligate; intracellular bacteria; progress; spp ... See more keywords
l-Lysine based lipidated biphenyls as agents with anti-biofilm and anti-inflammatory properties that also inhibit intracellular bacteria.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04206j
Abstract: l-Lysines were conjugated to lipidated biphenyls using simple synthetic chemistry to obtain selective membrane-active antibacterial agents that inhibit cell-wall biosynthesis. The most selective compound bore promising activity against biofilm-related infections and intracellular bacteria, and also… read more here.
Keywords: intracellular bacteria; lysine based; based lipidated; lipidated biphenyls ... See more keywords
Endocytosis-mediated redistribution of antibiotics targets intracellular bacteria.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr05421c
Abstract: The increasing emergence and dissemination of antibiotic resistance pose a severe threat to overwhelming healthcare practices worldwide. The lack of new antibacterial drugs urgently calls for alternative therapeutic strategies to combat multidrug-resistant (MDR) bacterial pathogens,… read more here.
Keywords: intracellular bacteria; redistribution antibiotics; endocytosis mediated; endocytosis ... See more keywords
Galleria mellonella–intracellular bacteria pathogen infection models: the ins and outs
Sign Up to like & getrecommendations! Published in 2023 at "FEMS Microbiology Reviews"
DOI: 10.1093/femsre/fuad011
Abstract: Abstract Galleria mellonella (greater wax moth) larvae are used widely as surrogate infectious disease models, due to ease of use and the presence of an innate immune system functionally similar to that of vertebrates. Here,… read more here.
Keywords: intracellular bacteria; infection models; bacteria pathogen; galleria mellonella ... See more keywords
Single-cell profiling identifies ACE+ granuloma macrophages as a nonpermissive niche for intracellular bacteria during persistent Salmonella infection
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1101/2022.07.21.501041
Abstract: Macrophages mediate key antimicrobial responses against intracellular bacterial pathogens, such as Salmonella enterica. Yet, they can also act as a permissive niche for these pathogens to persist in infected tissues within granulomas, which are immunological… read more here.
Keywords: persistent salmonella; intracellular bacteria; infection; niche ... See more keywords
NK cells promote intracellular infected trophoblasts survival via APOD-LRP1 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Immunology"
DOI: 10.1111/imm.13621
Abstract: NK cells are known for their potent ability to kill stressed cells, whereas host cells infected with intracellular bacteria may also be benefit from the selective killing function of NK cells and survive. The mechanism… read more here.
Keywords: lrp1; cells promote; infected trophoblasts; promote intracellular ... See more keywords
Bringing genetics to heretofore intractable obligate intracellular bacterial pathogens: Chlamydia and beyond
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010669
Abstract: As their designation implies, obligate intracellular bacteria are microbes that have developed lifestyles so closely entwined with the cells of the hosts they infect that they can reproduce only within the confines of these cells.… read more here.
Keywords: obligate intracellular; spp; intracellular bacteria; host ... See more keywords
Nanomedicines for the Efficient Treatment of Intracellular Bacteria: The “ART” Principle
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2021.775682
Abstract: Infections induced by bacteria at present are a severe threat to public health. Compared with extracellular bacteria, intracellular bacteria are harder to get rid of and readily induce chronic inflammation as well as autoimmune disorders.… read more here.
Keywords: treatment intracellular; intracellular bacteria; nanomedicines efficient; efficient treatment ... See more keywords