Antibacterial nanotruffles for treatment of intracellular bacterial infection.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.120344
Abstract: Bacterial pathogens residing in host macrophages in intracellular infections are hard to eradicate because traditional antibiotics do not readily enter the cells or get eliminated via efflux pumps. To overcome this challenge, we developed a… read more here.
Keywords: treatment intracellular; bacterial infection; pta; intracellular bacterial ... See more keywords
Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.
Sign Up to like & getrecommendations! Published in 2017 at "Cell reports"
DOI: 10.1016/j.celrep.2017.04.063
Abstract: Intestinal epithelial cells (IECs) act as sentinels for incoming pathogens. Cytosol-invasive bacteria, such as Shigella flexneri, trigger a robust pro-inflammatory nuclear factor κB (NF-κB) response from IECs that is believed to depend entirely on the… read more here.
Keywords: surveillance pathway; tifa dependent; cytosolic surveillance; dependent cytosolic ... See more keywords
Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridiumautoethanogenum Using Liquid Chromatography–Isotope Dilution Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2021 at "ACS Omega"
DOI: 10.1021/acsomega.0c05588
Abstract: We report a liquid chromatography–isotope dilution mass spectrometry method for the simultaneous quantification of 131 intracellular bacterial metabolites of Clostridium autoethanogenum. A comprehensive mixture of uniformly 13C-labeled internal standards (U-13C IS) was biosynthesized from the… read more here.
Keywords: chromatography isotope; dilution mass; mass spectrometry; liquid chromatography ... See more keywords
Selective treatment of intracellular bacterial infections using host cell-targeted bioorthogonal nanozymes.
Sign Up to like & getrecommendations! Published in 2022 at "Materials horizons"
DOI: 10.1039/d1mh02042k
Abstract: Intracellular bacterial infections are difficult to treat, and in the case of Salmonella and related infections, can be life threatening. Antibiotic treatments for intracellular infections face challenges including cell penetration and intracellular degradation that both… read more here.
Keywords: treatment intracellular; intracellular bacterial; cell; targeted bioorthogonal ... See more keywords
Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials science"
DOI: 10.1039/d2bm01489k
Abstract: The barrier function of host cells enables intracellular bacteria to evade the lethality of the host immune system and antibiotics, thereby causing chronic and recurrent infections that seriously threaten human health. Currently, the main clinical… read more here.
Keywords: intracellular bacterial; nanocarriers delivery; bacterial infections; delivery antibiotics ... See more keywords
Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens.
Sign Up to like & getrecommendations! Published in 2020 at "Pathogens and disease"
DOI: 10.1093/femspd/ftaa009
Abstract: Macrophages play an integral role in host defenses against intracellular bacterial pathogens. A remarkable plasticity allows for adaptation to the needs of the host to orchestrate versatile innate immune responses to a variety of microbial… read more here.
Keywords: macrophage polarization; host; bacterial pathogens; intracellular bacterial ... See more keywords
Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization
Sign Up to like & getrecommendations! Published in 2020 at "Infection and Immunity"
DOI: 10.1128/iai.00257-20
Abstract: Stealthy intracellular bacterial pathogens are known to establish persistent and sometimes lifelong infections. Some of these pathogens also have a tropism for the reproductive system, thereby increasing the risk of reproductive disease and infertility. To… read more here.
Keywords: intracellular bacterial; role; infection; brucella abortus ... See more keywords
Purification of Intracellular Bacterial Communities during Experimental Urinary Tract Infection Reveals an Abundant and Viable Bacterial Reservoir
Sign Up to like & getrecommendations! Published in 2018 at "Infection and Immunity"
DOI: 10.1128/iai.00740-17
Abstract: ABSTRACT Urinary tract infections (UTIs) are a major infection of humans, particularly affecting women. Recurrent UTIs can cause significant discomfort and expose patients to high levels of antibiotic use, which in turn contributes to the… read more here.
Keywords: urinary tract; purification intracellular; bacterial communities; infection ... See more keywords
The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection
Sign Up to like & getrecommendations! Published in 2018 at "Mediators of Inflammation"
DOI: 10.1155/2018/6587296
Abstract: T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation… read more here.
Keywords: th17 host; th17 il17; immunoregulation th17; intracellular bacterial ... See more keywords
Principles of intracellular bacterial pathogen spread from cell to cell
Sign Up to like & getrecommendations! Published in 2018 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1007380
Abstract: A subset of intracellular pathogens, including Listeria monocytogenes, Shigella flexneri, Rickettsia spp., and Burkholderia spp. disseminate within nonphagocytic cells, such as epithelial and endothelial cells, through a process referred to as cell-to-cell spread [1]. These… read more here.
Keywords: principles intracellular; cell; intracellular bacterial; spread ... See more keywords
Nanomaterials against intracellular bacterial infection: from drug delivery to intrinsic biofunction
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1197974
Abstract: Fighting intracellular bacteria with strong antibiotics evading remains a long-standing challenge. Responding to and regulating the infectious microenvironment is crucial for treating intracellular infections. Sophisticated nanomaterials with unique physicochemical properties exhibit great potential for precise… read more here.
Keywords: intracellular bacterial; infection; nanomaterials intracellular; drug delivery ... See more keywords