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   Articles with "intracellular bacterial" as a keyword



Antibacterial nanotruffles for treatment of intracellular bacterial infection.

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recommendations! Published in 2020 at "Biomaterials"

DOI: 10.1016/j.biomaterials.2020.120344

Abstract: Bacterial pathogens residing in host macrophages in intracellular infections are hard to eradicate because traditional antibiotics do not readily enter the cells or get eliminated via efflux pumps. To overcome this challenge, we developed a… read more here.

Keywords: treatment intracellular; bacterial infection; pta; intracellular bacterial ... See more keywords

Innate Recognition of Intracellular Bacterial Growth Is Driven by the TIFA-Dependent Cytosolic Surveillance Pathway.

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recommendations! Published in 2017 at "Cell reports"

DOI: 10.1016/j.celrep.2017.04.063

Abstract: Intestinal epithelial cells (IECs) act as sentinels for incoming pathogens. Cytosol-invasive bacteria, such as Shigella flexneri, trigger a robust pro-inflammatory nuclear factor κB (NF-κB) response from IECs that is believed to depend entirely on the… read more here.

Keywords: surveillance pathway; tifa dependent; cytosolic surveillance; dependent cytosolic ... See more keywords
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Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridiumautoethanogenum Using Liquid Chromatography–Isotope Dilution Mass Spectrometry

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recommendations! Published in 2021 at "ACS Omega"

DOI: 10.1021/acsomega.0c05588

Abstract: We report a liquid chromatography–isotope dilution mass spectrometry method for the simultaneous quantification of 131 intracellular bacterial metabolites of Clostridium autoethanogenum. A comprehensive mixture of uniformly 13C-labeled internal standards (U-13C IS) was biosynthesized from the… read more here.

Keywords: chromatography isotope; dilution mass; mass spectrometry; liquid chromatography ... See more keywords

Inhibition of neutrophil swarming by type I interferon promotes intracellular bacterial evasion

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-53060-4

Abstract: Listeria monocytogenes (LM) possesses the ability to breach multiple barriers and elicit intricate immune responses. However, there remains a lack of explicit understanding regarding how LM evades innate immune surveillance within the body. Here, we… read more here.

Keywords: type interferon; inhibition neutrophil; neutrophil swarming; intracellular bacterial ... See more keywords

Selective treatment of intracellular bacterial infections using host cell-targeted bioorthogonal nanozymes.

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recommendations! Published in 2022 at "Materials horizons"

DOI: 10.1039/d1mh02042k

Abstract: Intracellular bacterial infections are difficult to treat, and in the case of Salmonella and related infections, can be life threatening. Antibiotic treatments for intracellular infections face challenges including cell penetration and intracellular degradation that both… read more here.

Keywords: treatment intracellular; intracellular bacterial; cell; targeted bioorthogonal ... See more keywords

Nanocarriers for the delivery of antibiotics into cells against intracellular bacterial infection.

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recommendations! Published in 2022 at "Biomaterials science"

DOI: 10.1039/d2bm01489k

Abstract: The barrier function of host cells enables intracellular bacteria to evade the lethality of the host immune system and antibiotics, thereby causing chronic and recurrent infections that seriously threaten human health. Currently, the main clinical… read more here.

Keywords: intracellular bacterial; nanocarriers delivery; bacterial infections; delivery antibiotics ... See more keywords

Hacking the host: exploitation of macrophage polarization by intracellular bacterial pathogens.

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recommendations! Published in 2020 at "Pathogens and disease"

DOI: 10.1093/femspd/ftaa009

Abstract: Macrophages play an integral role in host defenses against intracellular bacterial pathogens. A remarkable plasticity allows for adaptation to the needs of the host to orchestrate versatile innate immune responses to a variety of microbial… read more here.

Keywords: macrophage polarization; host; bacterial pathogens; intracellular bacterial ... See more keywords

Brucella abortus and Pregnancy in Mice: Impact of Chronic Infection on Fertility and the Role of Regulatory T Cells in Tissue Colonization

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recommendations! Published in 2020 at "Infection and Immunity"

DOI: 10.1128/iai.00257-20

Abstract: Stealthy intracellular bacterial pathogens are known to establish persistent and sometimes lifelong infections. Some of these pathogens also have a tropism for the reproductive system, thereby increasing the risk of reproductive disease and infertility. To… read more here.

Keywords: intracellular bacterial; role; infection; brucella abortus ... See more keywords

Purification of Intracellular Bacterial Communities during Experimental Urinary Tract Infection Reveals an Abundant and Viable Bacterial Reservoir

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recommendations! Published in 2018 at "Infection and Immunity"

DOI: 10.1128/iai.00740-17

Abstract: ABSTRACT Urinary tract infections (UTIs) are a major infection of humans, particularly affecting women. Recurrent UTIs can cause significant discomfort and expose patients to high levels of antibiotic use, which in turn contributes to the… read more here.

Keywords: urinary tract; purification intracellular; bacterial communities; infection ... See more keywords

Urogenital microbiome, intracellular bacterial communities, and their contribution to urinary tract infections

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recommendations! Published in 2025 at "Microbiology Spectrum"

DOI: 10.1128/spectrum.01247-25

Abstract: ABSTRACT The urinary tract was long considered a sterile environment, but recent studies have revealed the presence of diverse microbial communities in healthy individuals collectively known as the urinary microbiome or urobiome. Although the urobiome… read more here.

Keywords: tract; microbial communities; intracellular bacterial; urinary tract ... See more keywords

The Immunoregulation of Th17 in Host against Intracellular Bacterial Infection

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recommendations! Published in 2018 at "Mediators of Inflammation"

DOI: 10.1155/2018/6587296

Abstract: T helper 17 cells (Th17) constitute a distinct subset of helper T cells with a unique transcriptional profile (STAT3, RORγ, and RORα), cytokine production pattern (IL17 family), and requirement of specific cytokines for their differentiation… read more here.

Keywords: th17 host; th17 il17; immunoregulation th17; intracellular bacterial ... See more keywords