Correlation between cellular uptake and cytotoxicity of fragmented α-synuclein amyloid fibrils suggests intracellular basis for toxicity.
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DOI: 10.1021/acschemneuro.9b00562
Abstract: Aggregation and intracellular deposition of the protein α-synuclein is an underlying characteristic of Parkinson's disease. α-synuclein assemblies also undergo cell-cell spreading, facilitating propagation of their cellular pathology. Understanding how cellular interactions and uptake of extracellular… read more here.
Keywords: synuclein; amyloid fibrils; intracellular basis; cytotoxicity ... See more keywords