A Model-Based Approach To Assessing the Importance of Intracellular Binding Sites in Doxorubicin Disposition.
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DOI: 10.1021/acs.molpharmaceut.6b00974
Abstract: Doxorubicin is an anticancer agent, which binds reversibly to topoisomerase I and II, intercalates to DNA base pairs, and generates free radicals. Doxorubicin has a high tissue:plasma partition coefficient and high intracellular binding to the… read more here.
Keywords: intracellular binding; semi pbpk; tissue; model ... See more keywords