Regulation of Distal Nephron Transport by Intracellular Chloride and Potassium
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DOI: 10.1159/000526051
Abstract: Background: Low potassium increases the phosphorylation and activity of the sodium chloride cotransporter (NCC) in the distal convoluted tubule of the nephron, which contributes to the hypertensive effect of the modern low potassium/high sodium diet.… read more here.
Keywords: nephron; potassium; intracellular chloride; distal ... See more keywords
Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension.
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DOI: 10.1165/rcmb.2022-0111oc
Abstract: Mitochondrial fission and a metabolic switch from oxidative phosphorylation to glycolysis are key features of vascular pathology in pulmonary arterial hypertension (PAH) and are associated with exuberant endothelial proliferation and apoptosis. The underlying mechanisms are… read more here.
Keywords: arterial hypertension; intracellular chloride; chloride channels; pulmonary arterial ... See more keywords
Long-Term Imaging Reveals a Circadian Rhythm of Intracellular Chloride in Neurons of the Suprachiasmatic Nucleus
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DOI: 10.1177/07487304211059770
Abstract: Both inhibitory and excitatory GABA transmission exist in the mature suprachiasmatic nucleus (SCN), the master pacemaker of circadian physiology. Whether GABA is inhibitory or excitatory depends on the intracellular chloride concentration ([Cl−]i). Here, using the… read more here.
Keywords: long term; intracellular chloride; vip neurons; suprachiasmatic nucleus ... See more keywords