Increased intracellular Cl- concentration by activating FAK promotes airway epithelial BEAS-2B cells proliferation and wound healing.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.108225
Abstract: An increase in intracellular Cl- concentration ([Cl-]i) may be a general response of airway epithelial cells to various stimuli and may participate in some basic cellular functions. However, whether the basic functional activities of cells,… read more here.
Keywords: proliferation wound; wound healing; intracellular concentration; beas cells ... See more keywords
Blockade of TMEM16A protects against renal fibrosis by reducing intracellular Cl- concentration.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of pharmacology"
DOI: 10.1111/bph.15786
Abstract: BACKGROUND AND PURPOSE Renal fibrosis is the final common outcome in most forms of CKD. However, the underlying causal mechanisms remain obscure. The present study examined whether TMEM16A, a Ca2+ -activated chloride channel, contributes to… read more here.
Keywords: expression; renal fibrosis; blockade tmem16a; intracellular concentration ... See more keywords