Atazanavir intracellular concentrations remain stable during pregnancy in HIV-infected patients
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DOI: 10.1093/jac/dkx274
Abstract: Background Atazanavir (300 mg) boosted by ritonavir (100 mg) is the preferred third drug in pregnancy. However, there is still discordance on atazanavir dose increase during the third trimester. Objectives To evaluate plasma and intracellular atazanavir and… read more here.
Keywords: pregnancy; intracellular concentrations; ritonavir; hiv infected ... See more keywords
Factors Influencing the Intracellular Concentrations of the Sofosbuvir Metabolite GS-331007 (in PBMCs) at 30 Days of Therapy
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DOI: 10.3390/ph15030355
Abstract: Sofosbuvir (SOF) is an HCV NS5B polymerase inhibitor, and GS-331007 is its major metabolite. The aim of this study was to investigate whether clinical and pharmacological factors could influence GS-331007 intracellular (IC) concentrations in peripheral… read more here.
Keywords: factors influencing; days therapy; patients treated; influencing intracellular ... See more keywords