Harnessing the Therapeutic Potential of Biomacromolecules through Intracellular Delivery of Nucleic Acids, Peptides, and Proteins
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102600
Abstract: Biomacromolecules have long been at the leading edge of academic and pharmaceutical drug development and clinical translation. With the clinical advances of new therapeutics, such as monoclonal antibodies and nucleic acids, the array of medical… read more here.
Keywords: nucleic acids; therapeutic potential; harnessing therapeutic; intracellular delivery ... See more keywords
Direct Intracellular Delivery of Cell‐Impermeable Probes of Protein Glycosylation by Using Nanostraws
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201600689
Abstract: Bioorthogonal chemistry is an effective tool for elucidating metabolic pathways and measuring cellular activity, yet its use is currently limited by the difficulty of getting probes past the cell membrane and into the cytoplasm, especially… read more here.
Keywords: delivery; direct intracellular; glycosylation; delivery cell ... See more keywords
Controlling and Monitoring Intracellular Delivery of Anticancer Polymer Nanomedicines.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700022
Abstract: Polymer nanomedicines are very attractive to improve the delivery of chemotherapeutics. Polymer conjugates and other polymer-based nanocarriers allow to increase plasma half-life and drug bioavailability and can also be guided toward tumors using passive and… read more here.
Keywords: controlling monitoring; monitoring intracellular; polymer; intracellular delivery ... See more keywords
Fluorous Tagged Peptides for Intracellular Delivery and Biomedical Imaging.
Sign Up to like & getrecommendations! Published in 2023 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202300048
Abstract: Fluorous tagged peptides have shown promising features for biomedical applications such as drug delivery and multimodal imaging. The bioconjugation of fluoroalkyl ligands onto cargo peptides greatly enhances their proteolytic stability and membrane penetration via a… read more here.
Keywords: peptides intracellular; delivery biomedical; tagged peptides; intracellular delivery ... See more keywords
Stimuli-responsive nanocarriers for intracellular delivery
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0341-z
Abstract: The emergence of different nanoparticles (NPs) has made a significant revolution in the field of medicine. Different NPs in the form of metallic NPs, dendrimers, polymeric NPs, carbon quantum dots and liposomes have been functionalized… read more here.
Keywords: medicine; delivery; responsive nanocarriers; stimuli responsive ... See more keywords
Intracellular Co-delivery of native antibody and siRNA for combination therapy by using biodegradable silica nanocapsules.
Sign Up to like & getrecommendations! Published in 2022 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2022.121376
Abstract: Combination therapy is a promising strategy for treating multidrug-resistant (MDR) cancers. Macromolecules such as antibodies and RNAs have been successfully used for targeted therapy owing to their high specificity. However, their application as therapeutics remains… read more here.
Keywords: combination therapy; combination; therapy; antibody ... See more keywords
Vapor nanobubble-mediated photoporation constitutes a versatile intracellular delivery technology
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Colloid and Interface Science"
DOI: 10.1016/j.cocis.2021.101453
Abstract: Abstract Vapor nanobubble (VNB)-mediated photoporation has evolved into a promising physical intracellular delivery technology. When irradiated with short but intense laser pulses, photothermal nanomaterials can generate VNBs that, when they collapse, induce transient membrane pores… read more here.
Keywords: vapor nanobubble; delivery technology; intracellular delivery; mediated photoporation ... See more keywords
Intracellular Delivery of HCV NS3p gene using vectored particles.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2018.03.010
Abstract: Viral hepatitis caused by the hepatitis C virus (HCV) affects millions of people worldwide. The non-structural protein 3 (NS3), one of the most conserved proteins in HCV, is the target of many therapeutic studies. The… read more here.
Keywords: hcv; hcv ns3p; delivery hcv; intracellular delivery ... See more keywords
Design of Polymeric Gene Carriers for Effective Intracellular Delivery.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biotechnology"
DOI: 10.1016/j.tibtech.2018.02.006
Abstract: Polymeric carriers have emerged as major non-viral alternatives for gene delivery due to their lower immunogenicity and pathogenicity. However, during intracellular delivery of these carriers, multiple barriers have to be overcome or the efficiency of… read more here.
Keywords: delivery; polymeric gene; design polymeric; gene delivery ... See more keywords
Sterically Bulky Caging of Transferrin for Photoactivatable Intracellular Delivery.
Sign Up to like & getrecommendations! Published in 2021 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.1c00159
Abstract: Photoactivatable ligand proteins are potentially useful for light-induced intracellular delivery of therapeutic and diagnostic cargos through receptor-mediated cellular uptake. Here, we report the simple and effective caging of transferrin (Tf), a representative ligand protein with… read more here.
Keywords: sterically bulky; delivery; bulky caging; cellular uptake ... See more keywords
Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules.
Sign Up to like & getrecommendations! Published in 2018 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00820
Abstract: We report the synthesis and characterization of phototriggerable polymeric nanoparticles (NPs) for the intracellular delivery of small molecules and proteins to modulate cell activity. For that purpose, several photocleavable linkers have been prepared providing diverse… read more here.
Keywords: nanoparticles conjugated; linkers intracellular; intracellular delivery; photocleavable linkers ... See more keywords