Response to Yang et. al
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Medicine"
DOI: 10.1007/s00109-019-01775-z
Abstract: To the editor: We would like to express our appreciation to Yang and colleagues for their constructive comments on our recent article entitled BNuclear localization of LDL receptorrelated protein 1B in mammary gland carcinogenesis^ [1].… read more here.
Keywords: cancer; response; intracellular domain; breast cancer ... See more keywords
Large Intracellular Domain-Dependent Effects of Positive Allosteric Modulators on Glycine Receptors.
Sign Up to like & getrecommendations! Published in 2019 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00050
Abstract: Glycine receptors (GlyRs) are members of the pentameric ligand-gated ionic channel family (pLGICs) and mediate fast inhibitory neurotransmission in the brain stem and spinal cord. The function of GlyRs can be modulated by positive allosteric… read more here.
Keywords: intracellular domain; allosteric modulators; sensitivity; glycine receptors ... See more keywords
FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells.
Sign Up to like & getrecommendations! Published in 2023 at "Neuro-oncology"
DOI: 10.1093/neuonc/noad079
Abstract: BACKGROUND Glioma stem cells (GSCs) are a subpopulation of tumor cells with self-renewal and tumorigenic capabilities in glioblastomas (GBMs). Diffuse infiltration of GSCs facilitates tumor progression and frustrates efforts at effective treatment. Further compounding this… read more here.
Keywords: glioma stem; self renewal; invasion; intracellular domain ... See more keywords
Melatonin Attenuates Vascular Smooth Muscle Contraction Through the γ-Secretase/Notch Intracellular Domain/Myocardin Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cardiovascular Pharmacology"
DOI: 10.1097/fjc.0000000000001322
Abstract: Supplemental Digital Content is Available in the Text. Abstract: Inositol 1, 4, 5-trisphosphate (IP3) signaling-mediated calcium release drives the contraction of vascular smooth muscles and hence regulates blood vessel volume and blood pressure. Melatonin supplementation… read more here.
Keywords: melatonin; notch intracellular; vascular smooth; intracellular domain ... See more keywords
Sirtuin1 meditated modification of Notch1 intracellular domain regulates nucleolar localization and activation of distinct signaling cascades
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.988816
Abstract: Notch signaling is involved in cell fate decisions in the development and maintenance of tissue homeostasis. Spatial regulation of the Notch1 intracellular domain (NIC1), has been shown to underpin signaling outcomes mediated by this receptor.… read more here.
Keywords: localization; anti apoptotic; notch1 intracellular; nucleolar localization ... See more keywords
Inhibition of the intracellular domain of Notch1 results in vascular endothelial cell dysfunction in sepsis
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1134556
Abstract: Background Notch signaling is critical for regulating the function of vascular endothelial cells (ECs). However, the effect of the intracellular domain of Notch1 (NICD) on EC injury in sepsis remains unclear. Methods We established a… read more here.
Keywords: sepsis; inhibition; dysfunction; domain notch1 ... See more keywords
CD51 Intracellular Domain Promotes Cancer Cell Neurotropism through Interacting with Transcription Factor NR4A3 in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15092623
Abstract: Simple Summary Perineural invasion is an important cause of postoperative recurrence and metastasis of colorectal cancer, but the mechanisms of perineural invasion are not well characterized. Meanwhile, there is no targeted therapy for perineural invasion… read more here.
Keywords: cd51; colorectal cancer; intracellular domain; cancer ... See more keywords
The Cell Adhesion Molecule L1 Interacts with Methyl CpG Binding Protein 2 via Its Intracellular Domain
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073554
Abstract: Cell adhesion molecule L1 regulates multiple cell functions, and L1 deficiency is linked to several neural diseases. Recently, we have identified methyl CpG binding protein 2 (MeCP2) as a potential binding partner of the intracellular… read more here.
Keywords: cell; cell adhesion; adhesion molecule; intracellular domain ... See more keywords
The function of Notch1 intracellular domain in the differentiation of gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8118
Abstract: Due to the complex function of the Notch signal pathway in gastric cancer (GC), the association between Notch homolog 1 (Notch1) intracellular domain (NICD) and differentiation of GC remains unknown. The present study aimed to… read more here.
Keywords: gastric cancer; notch1 intracellular; differentiation; intracellular domain ... See more keywords