Lipid-siRNA Organization Modulates the Intracellular Dynamics of Lipid Nanoparticles
Sign Up to like & getrecommendations! Published in 2025 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c18308
Abstract: Lipid nanoparticles (LNPs) are widely used for delivering therapeutic nucleic acids, yet the relationship between their internal structure and intracellular behavior, particularly before RNA release, remains unclear. Here, we elucidate how lipid-siRNA organization within LNPs… read more here.
Keywords: sirna organization; intracellular dynamics; organization modulates; lipid sirna ... See more keywords
Intracellular dynamics of polydnavirus innexin homologues
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DOI: 10.1111/imb.12657
Abstract: Polydnaviruses associated with ichneumonid parasitoid wasps (Ichnoviruses) encode large numbers of genes, often in multigene families. The Ichnovirus Vinnexin gene family, which is expressed in parasitized lepidopteran larvae, encodes homologues of Innexins, the structural components… read more here.
Keywords: intracellular dynamics; innexin homologues; inx2; polydnavirus innexin ... See more keywords
Quantitative prediction of intracellular dynamics and synaptic currents in a small neural circuit
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Computational Neuroscience"
DOI: 10.3389/fncom.2025.1515194
Abstract: Fitting models to experimental intracellular data is challenging. While detailed conductance-based models are difficult to train, phenomenological statistical models often fail to capture the rich intrinsic dynamics of circuits such as central pattern generators (CPGs).… read more here.
Keywords: circuit; neural circuit; intracellular dynamics; data driven ... See more keywords