Intracellular Enzyme-Responsive Profluorophore and Prodrug Nanoparticles for Tumor-Specific Imaging and Precise Chemotherapy.
Sign Up to like & getrecommendations! Published in 2021 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.1c19058
Abstract: Responsive drug delivery systems possess great potential in disease diagnosis and treatment. Herein, we develop an activatable prodrug and fluorescence imaging material by engineering the endogenous NAD(P)H:quinone oxidoreductase-1 (NQO1) responsive linker. The as-prepared nanomaterials possess… read more here.
Keywords: prodrug; chemotherapy; enzyme responsive; tumor specific ... See more keywords
Intracellular enzyme-powered DNA circuit with a tunable amplifier for miRNA imaging.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc00536g
Abstract: We describe an intracellular enzyme-powered DNA circuit probe with a tunable amplifier for sensitive and selective detection of miRNA. This approach has been successfully applied for in situ miRNA-21 fluorescence imaging in live cells. Also,… read more here.
Keywords: dna circuit; intracellular enzyme; enzyme powered; powered dna ... See more keywords
Intracellular Enzyme-Instructed Self-Assembly of Peptides (IEISAP) for Biomedical Applications
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27196557
Abstract: Despite the remarkable significance and encouraging breakthroughs of intracellular enzyme-instructed self-assembly of peptides (IEISAP) in disease diagnosis and treatment, a comprehensive review that focuses on this topic is still desirable. In this article, we carefully… read more here.
Keywords: assembly peptides; self assembly; intracellular enzyme; enzyme instructed ... See more keywords