Expression of Francisella pathogenicity island protein intracellular growth locus E (IglE) in mammalian cells is involved in intracellular trafficking, possibly through microtubule organizing center
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DOI: 10.1002/mbo3.684
Abstract: Francisella tularensis is the causative agent of the infectious disease tularemia and is designated a category A bioterrorism agent. The type VI secretion system encoded by the Francisella pathogenicity island (FPI) is necessary for intracellular… read more here.
Keywords: pathogenicity island; igle; intracellular growth; growth ... See more keywords
Free-Living Amoebae Supporting Intracellular Growth May Produce Vesicle-Bound Respirable Doses of Legionella Within Drinking Water Systems
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DOI: 10.1007/s12403-017-0255-9
Abstract: Legionella pneumophila has recently been described as a major cause of water-related outbreaks in developed countries. In drinking water distribution and premise plumbing systems, L. pneumophila grow within free-living amoeba hosts in biofilm. Exposure to… read more here.
Keywords: water; intracellular growth; free living; drinking water ... See more keywords
Oxadiazon Derivatives Elicit Potent Intracellular Growth Inhibition against Toxoplasma gondii by Disrupting Heme Biosynthesis.
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DOI: 10.1021/acsinfecdis.2c00020
Abstract: Infections of Toxoplasma gondii can cause severe and sometimes fatal diseases in immunocompromised individuals. The de novo heme biosynthesis pathway is required for intracellular growth and pathogenesis, making it an appealing therapeutic target. We synthesized… read more here.
Keywords: inhibition; gondii; intracellular growth; heme biosynthesis ... See more keywords
RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth.
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DOI: 10.1073/pnas.2122173119
Abstract: SignificanceRiboflavin (vitamin B2) is converted into flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are essential cofactors for many redox reactions across all domains of life. Listeria monocytogenes is a facultative intracellular pathogen that… read more here.
Keywords: fmn fad; fmn; ribu essential; intracellular growth ... See more keywords
Components of the endocytic and recycling trafficking pathways interfere with the integrity of the Legionella‐containing vacuole
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DOI: 10.1111/cmi.13151
Abstract: Legionella pneumophila requires the Dot/Icm translocation system to replicate in a vacuolar compartment within host cells. Strains lacking the translocated substrate SdhA form a permeable vacuole during residence in the host cell, exposing bacteria to… read more here.
Keywords: endocytic recycling; vacuole integrity; sdha mutant; sdha ... See more keywords
A Small RNA, SaaS, Promotes Salmonella Pathogenicity by Regulating Invasion, Intracellular Growth, and Virulence Factors
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DOI: 10.1128/spectrum.02938-22
Abstract: Salmonella is a zoonotic pathogen with high virulence worldwide, and sRNAs have recently been discovered to play important roles. We explored the biological characteristics of the sRNA SaaS and developed two cell infection models and… read more here.
Keywords: infection; intracellular growth; saas; invasion intracellular ... See more keywords
Genetically Related Mycobacterium bovis Strains Displayed Differential Intracellular Growth in Bovine Macrophages
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DOI: 10.3390/vetsci6040081
Abstract: Molecular typing of bacterial isolates provides a powerful approach for distinguishing Mycobacterium bovis (M. bovis) genotypes. It is known that M. bovis strain virulence plays a role in prevalence and spread of the disease, suggesting… read more here.
Keywords: mycobacterium bovis; bovis; bovis strains; intracellular growth ... See more keywords