Quantitative measurement of intracellular HDAC1/2 drug occupancy using a trans-cyclooctene largazole thiol probe.
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DOI: 10.1039/c6md00633g
Abstract: Histone deacetylases (HDACs) regulate diverse cellular processes, and are promising targets for a number of diseases. Here we describe the design and utilization of a largazole-based chemical probe to quantitatively measure the intracellular occupancy of… read more here.
Keywords: quantitative measurement; probe; measurement intracellular; drug ... See more keywords