Multiply Guaranteed and Successively Amplified Activation of a Catalytic DNA Machine for Highly Efficient Intracellular Imaging of MicroRNA.
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DOI: 10.1002/smll.202203341
Abstract: DNA amplification machines show great promise for intracellular imaging, yet are always constrained by off-site machinery activation or signal leakage, originating from the inherent thermodynamically driven hybridization between machinery substrates. Herein, an entropy-driven catalytic DNA… read more here.
Keywords: dna; machine; intracellular imaging; catalytic dna ... See more keywords
Highly sensitive detection and intracellular imaging of MicroRNAs based on target-triggered cascade catalytic hairpin assembly.
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DOI: 10.2139/ssrn.4145649
Abstract: MicroRNAs (miRNAs) have been identified as important biomarkers with great significance for diagnosis and treatment of various diseases. However, their unique properties, such as small size, high sequence homology, and low abundance, make quantitative analysis… read more here.
Keywords: hairpin assembly; intracellular imaging; cascade catalytic; catalytic hairpin ... See more keywords