An Integrated Approach to Elucidate the Interplay between Iron Uptake Dynamics and Magnetosome Formation at the Single-Cell Level in Magnetospirillum gryphiswaldense
Sign Up to like & getrecommendations! Published in 2024 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.4c15975
Abstract: Iron is a crucial element integral to various fundamental biological molecular mechanisms, including magnetosome biogenesis in magnetotactic bacteria (MTB). Magnetosomes are formed through the internalization and biomineralization of iron into magnetite crystals. However, the interconnected… read more here.
Keywords: iron uptake; single cell; iron; cell level ... See more keywords
Biomineralization of magnetic nanoparticles in stem cells.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d3nr00863k
Abstract: Iron is one of the most common metals in the human body, with an intrinsic metabolism including proteins involved in its transport, storage, and redox mechanisms. A less explored singularity is the presence of magnetic… read more here.
Keywords: iron; biomineralization magnetic; magnetic nanoparticles; intracellular iron ... See more keywords
A conserved two-component system senses intracellular iron levels and regulates redox balance in Mycobacterium spp.
Sign Up to like & getrecommendations! Published in 2024 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.01106-24
Abstract: ABSTRACT For bacteria, an intricate coordination between sensing and regulating iron levels and managing oxidative stress is required as their levels are tightly interlinked. While various oxidative stress and heme-based redox sensors have been reported… read more here.
Keywords: iron; oxidative stress; iron levels; sensor kinase ... See more keywords
Iron therapy mitigates chronic kidney disease progression by regulating intracellular iron status of kidney macrophages
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.159235
Abstract: Systemic iron metabolism is disrupted in chronic kidney disease (CKD). However, little is known about local kidney iron homeostasis and its role in kidney fibrosis. Kidney-specific effects of iron therapy in CKD also remain elusive.… read more here.
Keywords: kidney; iron; therapy; intracellular iron ... See more keywords
Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells.
Sign Up to like & getrecommendations! Published in 2018 at "Blood advances"
DOI: 10.1182/bloodadvances.2017015255
Abstract: Upon infection, pathogen and host compete for the same iron pool, because this trace metal is a crucial micronutrient for all living cells. Iron dysregulation in the host is strongly associated with poor outcomes in… read more here.
Keywords: iron; hepcidin ferroportin; iron sequestration; intracellular iron ... See more keywords
Helicobacter pylori infection perturbs iron homeostasis in gastric epithelial cells
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DOI: 10.1371/journal.pone.0184026
Abstract: The iron deficiency anaemia that often accompanies infection with Helicobacter pylori may reflect increased uptake of iron into gastric epithelial cells. Here we show an infection-associated increase in total intracellular iron levels was associated with… read more here.
Keywords: gastric epithelial; epithelial cells; intracellular iron; infection ... See more keywords
Cytochrome P450 1B1 Expression Regulates Intracellular Iron Levels and Oxidative Stress in the Retinal Endothelium
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032420
Abstract: Cytochrome P450 (CYP) 1B1 is a heme-containing monooxygenase found mainly in extrahepatic tissues, including the retina. CYP1B1 substrates include exogenous aromatic hydrocarbons, such as dioxins, and endogenous bioactive compounds, including 17β-estradiol (E2) and arachidonic acid.… read more here.
Keywords: iron; oxidative stress; cyp1b1; expression ... See more keywords